Samsung Medical Center, Department of Medicine, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.
Department of Medicine, Eulji General Hospital, Eulji University School of Medicine, Seoul 01830, Korea.
Nutrients. 2021 Mar 21;13(3):1013. doi: 10.3390/nu13031013.
Metabolic associated fatty liver disease (MAFLD) is a new concept where the presence of both fatty liver and metabolic abnormality are necessary for diagnosis. Several studies have reported that altered gut microbiome is closely associated with metabolic diseases and non-alcoholic fatty liver disease. However, the studies on MAFLD population are scarce. This prospective study aimed to identify differences in gut microbiome between patients with MAFLD and healthy controls in Korean population. In this study, patients with MAFLD and age, sex-matched healthy controls were included, and their stool samples were collected. Taxonomic composition of gut microbiota was analyzed using 16S ribosomal ribonucleic acid pyrosequencing. Twenty-two MAFLD patients and 44 healthy controls were included. Taxonomic diversity was lower in patients with MAFLD in the aspect of alpha and beta diversity. The differences were also found at phylum, class, family, and genus levels between the two groups. Phylum , family , genus abundance was significantly increased and genus was significantly decreased in patients with MAFLD. In addition, butyrate-producing bacteria were decreased and ethanol-producing bacteria were increased in patients with MAFLD. The composition of gut microbiome was different between MAFLD and healthy controls in Korean population. This could offer potential targets for therapeutic intervention in MAFLD.
代谢相关性脂肪性肝病（MAFLD）是一个新概念，其诊断需要同时存在脂肪肝和代谢异常。几项研究报告称，肠道微生物组的改变与代谢性疾病和非酒精性脂肪性肝病密切相关。然而，针对 MAFLD 人群的研究还很少。本前瞻性研究旨在确定韩国人群中 MAFLD 患者和健康对照者之间肠道微生物组的差异。在这项研究中，纳入了 MAFLD 患者和年龄、性别匹配的健康对照者，并采集了他们的粪便样本。使用 16S 核糖体核糖核酸焦磷酸测序分析肠道微生物群的分类组成。共纳入 22 名 MAFLD 患者和 44 名健康对照者。从α和β多样性方面来看，MAFLD 患者的肠道微生物多样性较低。两组之间在门、纲、科和属水平也存在差异。属的丰度显著增加，属的丰度显著降低。此外，MAFLD 患者中产生丁酸盐的细菌减少，产生乙醇的细菌增加。韩国人群中 MAFLD 与健康对照组的肠道微生物组组成不同。这可能为 MAFLD 的治疗干预提供潜在靶点。
