Anderson Cassidy, Brissette Catherine A
Department of Biomedical Sciences, University of North Dakota, Grand Forks, ND 58202, USA.
Pathogens. 2021 Mar 2;10(3):281. doi: 10.3390/pathogens10030281.
Lyme disease (LD) has become the most common vector-borne illness in the northern hemisphere. The causative agent, sensu lato, is capable of establishing a persistent infection within the host. This is despite the activation of both the innate and adaptive immune responses. utilizes several immune evasion tactics ranging from the regulation of surface proteins, tick saliva, antimicrobial peptide resistance, and the disabling of the germinal center. This review aims to cover the various methods by which evades detection and destruction by the host immune response, examining both the innate and adaptive responses. By understanding the methods employed by to evade the host immune response, we gain a deeper knowledge of pathogenesis and Lyme disease, and gain insight into how to create novel, effective treatments.
莱姆病（LD）已成为北半球最常见的媒介传播疾病。从广义上来说，其病原体能够在宿主体内建立持续感染。尽管激活了先天性和适应性免疫反应，但它仍能如此。它利用多种免疫逃避策略，包括表面蛋白的调控、蜱唾液、抗微生物肽抗性以及生发中心的失活。本综述旨在涵盖病原体逃避宿主免疫反应检测和破坏的各种方法，同时研究先天性和适应性免疫反应。通过了解病原体用于逃避宿主免疫反应的方法，我们对其发病机制和莱姆病有了更深入的认识，并深入了解如何开发新的有效治疗方法。
