Department of Biotechnology, Jozef Stefan Institute, SI-1000 Ljubljana, Slovenia.
Department of Surface Engineering, Jozef Stefan Institute, SI-1000 Ljubljana, Slovenia.
Molecules. 2021 Mar 2;26(5):1336. doi: 10.3390/molecules26051336.
Cold atmospheric plasma (CAP), an ionized gas operating at room temperature, has been increasingly studied with respect to its potential use in medicine, where its beneficial effects on tumor reduction in oncology have been demonstrated. This review discusses the cellular changes appearing in cell membranes, cytoplasm, various organelles, and DNA content upon cells' direct or indirect exposure to CAP or CAP-activated media/solutions (PAM), respectively. In addition, the CAP/PAM impact on the main cellular processes of proliferation, migration, protein degradation and various forms of cell death is addressed, especially in light of CAP use in the oncology field of plasma medicine.
冷等离体子体（CAP）是一种在室温下工作的离子化气体，其在医学上的潜在用途的研究日益增多，其在肿瘤学中减少肿瘤的有益效果已经得到证实。本文讨论了细胞在直接或间接暴露于 CAP 或 CAP 激活的介质/溶液（PAM）时，细胞膜、细胞质、各种细胞器和 DNA 含量中出现的细胞变化。此外，还讨论了 CAP/PAM 对细胞增殖、迁移、蛋白质降解和各种形式细胞死亡等主要细胞过程的影响，特别是鉴于 CAP 在等离子体医学的肿瘤学领域的应用。
