Research Group PLASMANT, Department of Chemistry, University of Antwerp, Universiteitsplein 1, B-2610 Wilrijk-Antwerp, Belgium.
Cells. 2020 Oct 21;9(10):2330. doi: 10.3390/cells9102330.
Cold atmospheric plasma (CAP) is a promising new agent for (selective) cancer treatment, but the underlying cause of the anti-cancer effect of CAP is not well understood yet. Among different theories and observations, one theory in particular has been postulated in great detail and consists of a very complex network of reactions that are claimed to account for the anti-cancer effect of CAP. Here, the key concept is a reactivation of two specific apoptotic cell signaling pathways through catalase inactivation caused by CAP. Thus, it is postulated that the anti-cancer effect of CAP is due to its ability to inactivate catalase, either directly or indirectly. A theoretical investigation of the proposed theory, especially the role of catalase inactivation, can contribute to the understanding of the underlying cause of the anti-cancer effect of CAP. In the present study, we develop a mathematical model to analyze the proposed catalase-dependent anti-cancer effect of CAP. Our results show that a catalase-dependent reactivation of the two apoptotic pathways of interest is unlikely to contribute to the observed anti-cancer effect of CAP. Thus, we believe that other theories of the underlying cause should be considered and evaluated to gain knowledge about the principles of CAP-induced cancer cell death.
冷等离体子体（CAP）是一种有前途的新型癌症治疗药物，但 CAP 抗癌效果的潜在原因尚未得到很好的理解。在不同的理论和观察中，有一种理论被详细地提出，它由一个非常复杂的反应网络组成，据称该网络解释了 CAP 的抗癌作用。在这里，关键概念是通过 CAP 引起的过氧化氢酶失活，重新激活两种特定的细胞凋亡信号通路。因此，有人假设 CAP 的抗癌作用是由于其能够直接或间接地使过氧化氢酶失活。对所提出理论的理论研究，特别是过氧化氢酶失活的作用，可以促进对 CAP 抗癌作用的潜在原因的理解。在本研究中，我们开发了一个数学模型来分析 CAP 的过氧化氢酶依赖性抗癌作用。我们的结果表明，感兴趣的两种细胞凋亡途径的过氧化氢酶依赖性再激活不太可能对 CAP 的观察到的抗癌作用做出贡献。因此，我们认为应该考虑和评估其他潜在原因的理论，以了解 CAP 诱导癌细胞死亡的原理。
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