Angiolillo Antonella, Leccese Deborah, Palazzo Marisa, Vizzarri Francesco, Casamassima Donato, Corino Carlo, Di Costanzo Alfonso
Centre for Research and Training in Medicine of Aging, Department of Medicine and Health Sciences "V. Tiberio", University of Molise, 86100 Campobasso, Italy.
Department of Agricultural, Environmental and Food Sciences, University of Molise, 86100 Campobasso, Italy.
Antioxidants (Basel). 2021 Mar 27;10(4):521. doi: 10.3390/antiox10040521.
is a plant traditionally used for its anti-inflammatory, antioxidant and antispasmodic effects, as well as for additional biological activities proven in cell culture, animal studies and a small number of human clinical trials. The plant has also shown a marked improvement in blood lipid profile in some animal species. In the present preliminary study, we investigated the effect of a leaf extract on lipid and oxidative blood profile of hypercholesterolemic volunteers. Twelve adults received extract caps, containing 23% phenylpropanoids, (100 mg, once a day) for 16 weeks. Selected blood lipids and plasma oxidative markers were measured at baseline and after 4, 8 and 16 weeks of treatment. Compared with baseline, total cholesterol levels significantly decreased and high-density lipoprotein cholesterol increased, while low-density lipoprotein cholesterol and triglycerides showed only a downward trend. Oxidative status was improved due to a decrease in the concentration of total oxidant status, reactive oxygen metabolites and malondialdehyde, and a significant increase in ferric reducing ability of plasma, vitamin A and vitamin E. These preliminary results suggest that dietary supplementation with extract can improve the lipid profile, enhance blood antioxidant power, and could be a valuable natural compound for the management of human hypercholesterolemia.
是一种传统上因其抗炎、抗氧化和抗痉挛作用以及在细胞培养、动物研究和少数人体临床试验中得到证实的其他生物活性而被使用的植物。该植物在一些动物物种中还显示出血脂谱有明显改善。在本初步研究中，我们调查了一种叶提取物对高胆固醇血症志愿者血脂和氧化血液指标的影响。12名成年人服用含有23%苯丙素类化合物的提取物胶囊（100毫克，每天一次），持续16周。在基线以及治疗4周、8周和16周后测量选定的血脂和血浆氧化标志物。与基线相比，总胆固醇水平显著降低，高密度脂蛋白胆固醇升高，而低密度脂蛋白胆固醇和甘油三酯仅呈下降趋势。由于总氧化状态、活性氧代谢物和丙二醛浓度降低，以及血浆铁还原能力、维生素A和维生素E显著增加，氧化状态得到改善。这些初步结果表明，用提取物进行膳食补充可以改善血脂谱，增强血液抗氧化能力，并且可能是用于管理人类高胆固醇血症的一种有价值的天然化合物。
