Montes Nuria, Cobos Alberto, Gil-Valle Miriam, Caro Elena, Pagán Israel
Unidad de Fisiología Vegetal, Departamento Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU Universities, Boadilla del Monte, 28003 Madrid, Spain.
Servicio de Reumatología, Hospital Universitario de la Princesa, Instituto de Investigación Sanitaria (IIS-IP), 28006 Madrid, Spain.
Microorganisms. 2021 Mar 27;9(4):692. doi: 10.3390/microorganisms9040692.
Virulence, the effect of pathogen infection on progeny production, is a major determinant of host and pathogen fitness as it affects host fecundity and pathogen transmission. In plant-virus interactions, ample evidence indicates that virulence is genetically controlled by both partners. However, the host genetic determinants are poorly understood. Through a genome-wide association study (GWAS) of 154 genotypes infected by (CMV), we identified eight host genes associated with virulence, most of them involved in response to biotic stresses and in cell wall biogenesis in plant reproductive structures. Given that virulence is a main determinant of the efficiency of plant virus seed transmission, we explored the link between this trait and the genetic regulation of virulence. Our results suggest that the same functions that control virulence are also important for CMV transmission through seeds. In sum, this work provides evidence of a novel role for some previously known plant defense genes and for the cell wall metabolism in plant virus interactions.
毒力是指病原体感染对后代繁殖的影响，它是宿主和病原体适应性的主要决定因素，因为它会影响宿主的繁殖力和病原体的传播。在植物与病毒的相互作用中，大量证据表明毒力受到双方的遗传控制。然而，宿主的遗传决定因素却知之甚少。通过对154种受黄瓜花叶病毒（CMV）感染的基因型进行全基因组关联研究（GWAS），我们鉴定出了8个与毒力相关的宿主基因，其中大多数基因参与植物对生物胁迫的反应以及植物生殖结构中的细胞壁生物合成。鉴于毒力是植物病毒种子传播效率的主要决定因素，我们探究了这一性状与毒力遗传调控之间的联系。我们的结果表明，控制毒力的相同功能对于CMV通过种子传播也很重要。总之，这项工作为一些先前已知的植物防御基因以及细胞壁代谢在植物与病毒相互作用中的新作用提供了证据。
