药物基因组学决定个体间药物反应变异性：从发现到实施。
Pharmacogenomic Determinants of Interindividual Drug Response Variability: From Discovery to Implementation.
机构信息
Department of Pathology, Stanford University, Stanford, CA 94305, USA.
Clinical Genomics Laboratory, Stanford Health Care, Palo Alto, CA 94304, USA.
出版信息
Genes (Basel). 2021 Mar 10;12(3):393. doi: 10.3390/genes12030393.
Abstract
Since the term "pharmacogenetics" was first published in the late 1950s by Friedrich Vogel, the field has evolved into genome-wide association studies identifying novel variants associated with drug response phenotypes, international societies and consortia dedicated to pharmacogenomic research and clinical implementation, clinical practice guidelines, and the increasing availability of pharmacogenomic tests for healthcare providers in both hospital and primary care [...].
摘要
自 20 世纪 50 年代末 Friedrich Vogel 首次提出“药物遗传学”一词以来，该领域已发展为全基因组关联研究，确定与药物反应表型相关的新型变体、致力于药物基因组学研究和临床实施的国际学会和联盟、临床实践指南，以及越来越多的药物基因组学检测可供医院和初级保健提供者使用[... ]。
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