Sanford Health Imagenetics, Sioux Falls, SD 57105, USA.
North Dakota State University College of Health Professions Department of Pharmacy Practice, Fargo, ND 58108, USA.
Pharmacogenomics. 2019 Aug;20(12):903-913. doi: 10.2217/pgs-2019-0043.
The convergence of translational genomics and biomedical informatics has changed healthcare delivery. Institutional consortia have begun implementing lab testing and decision support for drug-gene interactions. Aggregate datasets are now revealing the impact of clinical decision support for drug-gene interactions. Given the pleiotropic nature of pharmacogenes, interdisciplinary teams and robust clinical decision support tools must exist within an informatics framework built to be flexible and capable of cross-talk between clinical specialties. Navigation of the challenges presented with the implementation of five steps to build a genetics program infrastructure requires the expertise of multiple healthcare professionals. Ultimately, this manuscript describes our efforts to place pharmacogenomics in the hands of the primary care provider integrating this information into a patient's healthcare over their lifetime.
转化基因组学和生物医学信息学的融合改变了医疗保健的提供方式。机构联盟已经开始实施实验室测试和药物-基因相互作用的决策支持。现在，综合数据集正在揭示药物-基因相互作用的临床决策支持的影响。鉴于药物基因组的多效性，必须在一个信息学框架内建立跨学科团队和强大的临床决策支持工具，该框架必须具有灵活性，并能够在临床专业之间进行交流。实施构建遗传计划基础设施的五个步骤所带来的挑战需要多个医疗保健专业人员的专业知识。最终，本文描述了我们努力将药物基因组学置于初级保健提供者手中，将这些信息整合到患者的终身医疗保健中。
