Bae Jaehyun, Won Young Jun, Lee Byung-Wan
Division of Endocrinology and Metabolism, Department of Internal Medicine, Catholic Kwandong University College of Medicine, International St. Mary's Hospital, Incheon KS006, Korea.
Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul KS013, Korea.
Life (Basel). 2021 Mar 10;11(3):224. doi: 10.3390/life11030224.
Diabetic kidney disease (DKD) is one of the most common forms of chronic kidney disease. Its pathogenic mechanism is complex, and it can affect entire structures of the kidney. However, conventional approaches to early stage DKD have focused on changes to the glomerulus. Current standard screening tools for DKD, albuminuria, and estimated glomerular filtration rate are insufficient to reflect early tubular injury. Therefore, many tubular biomarkers have been suggested. Non-albumin proteinuria (NAP) contains a wide range of tubular biomarkers and is convenient to measure. We reviewed the clinical meanings of NAP and its significance as a marker for early stage DKD.
糖尿病肾病（DKD）是慢性肾病最常见的形式之一。其致病机制复杂，可影响肾脏的整个结构。然而，早期DKD的传统研究方法主要集中在肾小球的变化上。目前DKD、蛋白尿和估计肾小球滤过率的标准筛查工具不足以反映早期肾小管损伤。因此，人们提出了许多肾小管生物标志物。非白蛋白蛋白尿（NAP）包含多种肾小管生物标志物，且便于测量。我们综述了NAP的临床意义及其作为早期DKD标志物的重要性。
