Division of Applied RI, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Korea.
Korea Drug Development Platform Using Radio-Isotope, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Korea.
Int J Mol Sci. 2021 Mar 3;22(5):2522. doi: 10.3390/ijms22052522.
Early life stress (ELS) is strongly associated with psychiatric disorders such as anxiety, depression, and schizophrenia in adulthood. To date, biological, behavioral, and structural aspects of ELS have been studied extensively, but their functional effects remain unclear. Here, we examined NeuroPET studies of dopaminergic, glutamatergic, and serotonergic systems in ELS animal models. Maternal separation and restraint stress were used to generate single or complex developmental trauma. Body weights of animals exposed to single trauma were similar to those of control animals; however, animals exposed to complex trauma exhibited loss of body weight when compared to controls. In behavioral tests, the complex developmental trauma group exhibited a decrease in time spent in the open arm of the elevated plus-maze and an increase in immobility time in the forced swim test when compared to control animals. In NeuroPET studies, the complex trauma group displayed a reduction in brain uptake values when compared to single trauma and control groups. Of neurotransmitter systems analyzed, the rate of decrease in brain uptake was the highest in the serotonergic group. Collectively, our results indicate that developmental trauma events induce behavioral deficits, including anxiety- and depressive-like phenotypes and dysfunction in neurotransmitter systems.
早期生活应激（ELS）与成年期的焦虑、抑郁和精神分裂症等精神障碍密切相关。迄今为止，ELS 的生物学、行为学和结构方面已经得到了广泛的研究，但它们的功能影响仍不清楚。在这里，我们检查了 ELS 动物模型中多巴胺能、谷氨酸能和 5-羟色胺能系统的神经 PET 研究。母体分离和束缚应激被用来产生单一或复杂的发育性创伤。暴露于单一创伤的动物的体重与对照动物相似；然而，与对照组相比，暴露于复杂创伤的动物体重减轻。在行为测试中，与对照动物相比，复杂发育性创伤组在高架十字迷宫的开放臂中花费的时间减少，强迫游泳试验中的不动时间增加。在神经 PET 研究中，与单一创伤和对照组相比，复杂创伤组的脑摄取值降低。在分析的神经递质系统中，脑摄取率下降幅度最高的是 5-羟色胺能系统。总的来说，我们的结果表明，发育性创伤事件会引起行为缺陷，包括焦虑和抑郁样表型以及神经递质系统的功能障碍。
