Pasternak Andrew V, Fiore David, Islas Arthur, Toti Sarah, Hoffman Martin D
Silver Sage Center for Family Medicine, Reno, NV 89521, USA.
Department of Family and Community Medicine, Reno School of Medicine, University of Nevada, Reno, NV 89557, USA.
Sports (Basel). 2021 Mar 3;9(3):35. doi: 10.3390/sports9030035.
Nausea and vomiting are common for runners during ultramarathons and often contribute to non-finishes. We aimed to determine the efficacy of ondansetron, a commonly used antiemetic, to treat nausea and vomiting in runners during an ultramarathon. Runners who had a previous history of frequent nausea or vomiting during races and entered in 160, 80, and 55 km ultramarathons in 2018 and 2019 were randomized in a double-blind fashion to 4 mg ondansetron or placebo capsules to use if they developed nausea or vomiting during the race with the ability to take three additional doses. Study participants completed a post-race online survey to assess medication use and efficacy. Of 62 study participants, 31 took either ondansetron (20) or placebo (11). In this small study, there were no group differences in those reporting any improvement in nausea and vomiting ( = 0.26) or in the amount of improvement ( = 0.15). We found no evidence that ondansetron capsules improve nausea and vomiting during ultramarathons.
在超级马拉松比赛期间，恶心和呕吐对跑步者来说很常见，并且常常导致无法完赛。我们旨在确定常用止吐药昂丹司琼治疗超级马拉松比赛期间跑步者恶心和呕吐的疗效。在2018年和2019年参加过160公里、80公里和55公里超级马拉松比赛且之前在比赛中有频繁恶心或呕吐病史的跑步者，以双盲方式随机分为服用4毫克昂丹司琼或安慰剂胶囊组，若他们在比赛中出现恶心或呕吐，可额外服用三剂。研究参与者完成了一项赛后在线调查，以评估药物使用情况和疗效。在62名研究参与者中，31人服用了昂丹司琼（20人）或安慰剂（11人）。在这项小型研究中，报告恶心和呕吐有任何改善的人群（P = 0.26）或改善程度（P = 0.15）在两组之间没有差异。我们没有发现证据表明昂丹司琼胶囊能改善超级马拉松比赛期间的恶心和呕吐。
