Scheibel A B, Duong T
Department of Anatomy, UCLA Medical Center 90024.
Neurobiol Aging. 1988 Jan-Feb;9(1):41-2. doi: 10.1016/s0197-4580(88)80014-9.
A group of alterations in the structure of cortical microvessels is described in the brain tissue of neuropathologically confirmed patients with Alzheimer's disease. These changes include irregular thickening of the vessel walls, infiltration with amyloid and the serum P component of amyloid, loss of the perivascular neural plexus and the frequent occurrence of pits and lacunae in vessel walls. The possibility that these alterations may be related to blood brain barrier defects is suggested.
在经神经病理学确诊的阿尔茨海默病患者的脑组织中，描述了一组皮质微血管结构的改变。这些变化包括血管壁不规则增厚、淀粉样蛋白和淀粉样蛋白血清P成分浸润、血管周围神经丛丧失以及血管壁中频繁出现凹坑和腔隙。有人提出这些改变可能与血脑屏障缺陷有关。
