Wang Xiaheng, Fan Houyou, Zhang Feng, Zhao Siyu, Liu Yuxiao, Xu Yingying, Wu Runfa, Li Dongfang, Yang Yang, Liao Lan, Zhu Hongshui, Wang Xiaolei
The Key Laboratory of Oral Biomedicine, Jiangxi Province, The Affiliated Stomatological Hospital of Nanchang University, Nanchang, Jiangxi 330080, China.
The National Engineering Research Center for Bioengineering Drugs and the Technologies; Institute of Translational Medicine, Nanchang University, Nanchang, Jiangxi 330031, China.
ACS Biomater Sci Eng. 2020 Apr 13;6(4):1880-1886. doi: 10.1021/acsbiomaterials.9b01695. Epub 2020 Mar 12.
Dental implant surgery has a relatively high incidence of peri-implantitis. In this research, ZnO nanorods and ZnO nanospheres were synthesized by a hydrothermal method. ZnO nanorods first covered the surface of Ti or Ti-Zr, and ZnO nanospheres were then modified as the outermost layer. By these means a dual antibacterial effect could be realized by the rapid release of ZnO nanospheres and the sustained release of ZnO nanorods. Subsequent studies implied that this ZnO nanorods-nanospheres hierarchical structure (NRS) could be stably loaded on the surface of roughened Ti and Ti-Zr slices. The modified materials not only showed excellent antibacterial activities against both and but also showed low cellular cytotoxicity. This ZnO NRS structure is thus expected to be used as a general antimicrobial coating on the surface of Ti (Ti-Zr) in dental implant surgery.
牙种植手术中种植体周围炎的发生率相对较高。在本研究中，采用水热法合成了氧化锌纳米棒和氧化锌纳米球。氧化锌纳米棒首先覆盖钛或钛锆表面，然后将氧化锌纳米球修饰为最外层。通过这些方法，可通过氧化锌纳米球的快速释放和氧化锌纳米棒的持续释放实现双重抗菌效果。后续研究表明，这种氧化锌纳米棒-纳米球分级结构（NRS）可以稳定地负载在粗糙的钛和钛锆切片表面。改性材料不仅对[具体细菌名称1]和[具体细菌名称2]均表现出优异的抗菌活性，而且细胞毒性较低。因此，这种氧化锌NRS结构有望用作牙种植手术中钛（钛锆）表面的通用抗菌涂层。
