Osikowicz Lynn M, Horiuchi Kalanthe, Goodrich Irina, Breitschwerdt Edward B, Chomel Bruno, Biggerstaff Brad J, Kosoy Michael
Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO 80521, USA.
Comparative Medicine Institute, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA.
Pathogens. 2021 Mar 17;10(3):354. doi: 10.3390/pathogens10030354.
Cat-associated species, which include , , and can cause mild to severe illness in humans. In the present study, we evaluated 1362 serum samples obtained from domestic cats across the U.S. for seroreactivity against three species and two strain types of associated with cats ( type 1, type 2, , and ) using an indirect immunofluorescent assay (IFA). Overall, the seroprevalence at the cutoff titer level of ≥1:64 was 23.1%. Seroreactivity was 11.1% and 3.7% at the titer level cutoff of ≥1:128 and at the cutoff of ≥1:256, respectively. The highest observation of seroreactivity occurred in the East South-Central, South Atlantic, West North-Central, and West South-Central regions. The lowest seroreactivity was detected in the East North-Central, Middle Atlantic, Mountain, New England, and Pacific regions. We observed reactivity against all four spp. antigens in samples from eight out of the nine U.S. geographic regions.
与猫相关的物种，包括[具体物种1]、[具体物种2]和[具体物种3]，可导致人类出现轻度至重度疾病。在本研究中，我们使用间接免疫荧光法（IFA）评估了从美国各地家猫采集的1362份血清样本，检测其对与猫相关的三种物种和两种菌株类型（[菌株类型1]、[菌株类型2]、[菌株类型3]和[菌株类型4]）的血清反应性。总体而言，截断滴度水平≥1:64时的血清阳性率为23.1%。截断滴度水平≥1:128和≥1:256时的血清反应性分别为11.1%和3.7%。血清反应性最高的情况出现在东中南部、南大西洋、西北中部和西南中部地区。血清反应性最低的情况出现在东北中部、中大西洋、山区、新英格兰和太平洋地区。我们在美国九个地理区域中的八个区域的样本中观察到了针对所有四种[物种名称]抗原的反应性。
