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姜黄素改善C2C12成肌细胞中与氧化应激和炎症相关的肌肉疾病。

Curcumin Ameliorated Oxidative Stress and Inflammation-Related Muscle Disorders in C2C12 Myoblast Cells.

作者信息

Lee Da-Yeon, Chun Yoon-Seok, Kim Jong-Kyu, Lee Jeong-Ok, Lee Young-Joon, Ku Sae-Kwang, Shim Soon-Mi

机构信息

Department of Food Science and Biotechnology, Sejong University, 209, Neungdong-ro, Gwangjin-gu, Seoul 05006, Korea.

Aribio H&B Co., Ltd., #710, Yongin Techno Valley, 357, Guseong-ro, Giheung-gu, Yongin-si, Gyeonggi-do 16914, Korea.

出版信息

Antioxidants (Basel). 2021 Mar 17;10(3):476. doi: 10.3390/antiox10030476.

DOI:10.3390/antiox10030476
PMID:33802935
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8002759/
Abstract

The purpose of the current study was to investigate antioxidant and anti-inflammatory effects of spray dry powder containing 40% curcumin (CM-SD) in C2C12 myoblast cells. CM-SD increased DPPH radical scavenging activity in a dose-dependent manner, and up to 30 μg/mL of CM-SD did not express cytotoxicity in C2C12 cells. Exposure to hydrogen peroxide (HO) drastically decreased the viability of C2C12 cells, but pre-treatment of CM-SD significantly increased the cell viability ( < 0.01). CM-SD significantly transactivated the nuclear factor erythroid-2-related factor 2 (Nrf2)-dependent luciferase activity in a dose-dependent manner and enhanced the levels of heme oxygenase (HO)-1, glutamate cysteine ligase catalytic subunit (GCLC), and NAD(P)H-dependent quinone oxidoreductase (NQO)-1. CM-SD also significantly reduced reactive oxygen species (ROS) production and lipid peroxidation and restored glutathione (GSH) depletion in HO-treated C2C12 cells. Moreover, CM-SD significantly reduced lipopolysaccharides (LPS)-mediated interleukin (IL)-6 production in the conditioned medium. Results from the current study suggest that CM-SD could be a useful candidate against oxidative stress and inflammation-related muscle disorders.

摘要

本研究的目的是调查含40%姜黄素的喷雾干燥粉末（CM-SD）对C2C12成肌细胞的抗氧化和抗炎作用。CM-SD以剂量依赖性方式增加DPPH自由基清除活性，且高达30μg/mL的CM-SD在C2C12细胞中未表现出细胞毒性。暴露于过氧化氢（HO）会显著降低C2C12细胞的活力，但CM-SD预处理可显著提高细胞活力（<0.01）。CM-SD以剂量依赖性方式显著激活核因子红细胞2相关因子2（Nrf2）依赖性荧光素酶活性，并提高血红素加氧酶（HO）-1、谷氨酸半胱氨酸连接酶催化亚基（GCLC）和NAD（P）H依赖性醌氧化还原酶（NQO）-1的水平。CM-SD还显著降低HO处理的C2C12细胞中的活性氧（ROS）产生和脂质过氧化，并恢复谷胱甘肽（GSH）耗竭。此外，CM-SD显著降低条件培养基中脂多糖（LPS）介导的白细胞介素（IL）-6产生。本研究结果表明，CM-SD可能是对抗氧化应激和炎症相关肌肉疾病的有用候选物。

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