营养保健品在因炎症活动导致的心力衰竭肌肉萎缩中的作用。国际脂质专家小组（ILEP）立场文件。
The role of nutraceuticals in heart failure muscle wasting as a result of inflammatory activity. The International Lipid Expert Panel (ILEP) Position Paper.
作者信息
Bielecka-Dabrowa Agata, Banach Maciej, Wittczak Andrzej, Cicero Arrigo F G, Kallel Amani, Kubilius Raimondas, Mikhailidis Dimitri P, Sahebkar Amirhossein, Pantea Stoian Anca, Vinereanu Dragos, Penson Peter E, von Haehling Stephan
机构信息
Department of Preventive Cardiology and Lipidology, Medical University of Lodz (MUL), Lodz, Poland.
Department of Cardiology and Congenital Diseases of Adults, Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland.
出版信息
Arch Med Sci. 2023 Jun 9;19(4):841-864. doi: 10.5114/aoms/167799. eCollection 2023.
Muscle wasting is one of the main causes for exercise intolerance and ventilatory inefficiency in patients with heart failure and a strong predictor of frailty and reduced survival. The prevalence of sarcopenia is at least 20% in patients with heart failure. Patients with heart failure often have subclinical systemic inflammation, which may exert sustained effects on skeletal muscle. Besides exercise, nutrition should also be carefully evaluated as an appropriate diet with selected nutraceuticals may be able to stimulate muscle anabolism and inhibit muscle catabolism. This review summarizes the epidemiological and clinical trial evidence supporting the recommendations for the use of nutraceuticals with anti-inflammatory properties in heart failure and provides an overview of the state of the evidence for nutraceutical supplementation to prevent and/or mitigate heart failure muscle wasting.
肌肉萎缩是心力衰竭患者运动不耐受和通气效率低下的主要原因之一，也是虚弱和生存率降低的有力预测指标。心力衰竭患者中肌肉减少症的患病率至少为20%。心力衰竭患者常伴有亚临床全身性炎症，这可能对骨骼肌产生持续影响。除了运动之外，营养也应仔细评估，因为选择合适的营养保健品的适当饮食可能能够刺激肌肉合成代谢并抑制肌肉分解代谢。本综述总结了支持在心力衰竭中使用具有抗炎特性的营养保健品的建议的流行病学和临床试验证据，并概述了营养保健品补充剂预防和/或减轻心力衰竭肌肉萎缩的证据状况。
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