Daniele A, Guarini A, Summa S De, Dellino M, Lerario G, Ciavarella S, Ditonno P, Paradiso A V, Divella R, Casamassima P, Savino E, Carbonara M D, Minoia C
Experimental Oncology and Biobank Management Unit-IRCCS Istituto Tumori "Giovanni Paolo II", 70124 Bari, Italy.
Hematology Unit-IRCCS Istituto Tumori "Giovanni Paolo II", 70124 Bari, Italy.
J Pers Med. 2021 Mar 17;11(3):215. doi: 10.3390/jpm11030215.
Unhealthy lifestyle, as sedentary, unbalanced diet, smoking, and body composition change are often observed in non-Hodgkin's lymphoma (NHL) survivors, and could be determinant for the onset of cancer treatment-induced metabolic syndrome (CTIMetS), including abdominal obesity, sarcopenia, and insulin resistance. The aim of this study was to assess whether changes in body composition, unhealthy lifestyles and types of anti-cancer treatment could increase the risk of metabolic syndrome (MetSyn) and sarcopenia in long-term NHL survivors. We enrolled 60 consecutive NHL patients in continuous remission for at least 3 years. Nutritional status was assessed by anthropometry-plicometry, and a questionnaire concerning lifestyles and eating habits was administered. More than 60% of survivors exhibited weight gain and a change in body composition, with an increased risk of MetSyn. Univariate analysis showed a significantly higher risk of metabolic disorder in patients treated with steroids, and in patients with unhealthy lifestyles. These data suggest that a nutritional intervention, associated with adequate physical activity and a healthier lifestyle, should be indicated early during the follow-up of lymphoma patients, in order to decrease the risk of MetSyn's onset and correlated diseases in the long term.
在非霍奇金淋巴瘤（NHL）幸存者中，经常会观察到不健康的生活方式，如久坐不动、饮食不均衡、吸烟以及身体成分改变，这些可能是导致癌症治疗引起的代谢综合征（CTIMetS）发病的决定性因素，CTIMetS包括腹部肥胖、肌肉减少症和胰岛素抵抗。本研究的目的是评估身体成分变化、不健康生活方式和抗癌治疗类型是否会增加长期NHL幸存者发生代谢综合征（MetSyn）和肌肉减少症的风险。我们连续招募了60例持续缓解至少3年的NHL患者。通过人体测量-皮褶测量法评估营养状况，并发放了一份关于生活方式和饮食习惯的问卷。超过60%的幸存者出现体重增加和身体成分变化，患MetSyn的风险增加。单因素分析显示，接受类固醇治疗的患者以及生活方式不健康的患者发生代谢紊乱的风险显著更高。这些数据表明，在淋巴瘤患者的随访早期就应进行营养干预，并结合适当的体育活动和更健康的生活方式，以长期降低MetSyn发病及相关疾病的风险。
