S S Dos Santos Paulo, M M M de Almeida José, Pastoriza-Santos Isabel, C C Coelho Luís
INESC TEC-Institute for Systems and Computer Engineering, Technology and Science, and Faculty of Sciences, University of Porto, Rua do Campo Alegre, 4169-007 Porto, Portugal.
Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal.
Sensors (Basel). 2021 Mar 17;21(6):2111. doi: 10.3390/s21062111.
Surface plasmon resonance (SPR) and localized surface plasmon resonance (LSPR) are among the most common and powerful label-free refractive index-based biosensing techniques available nowadays. Focusing on LSPR sensors, their performance is highly dependent on the size, shape, and nature of the nanomaterial employed. Indeed, the tailoring of those parameters allows the development of LSPR sensors with a tunable wavelength range between the ultra-violet (UV) and near infra-red (NIR). Furthermore, dealing with LSPR along optical fiber technology, with their low attenuation coefficients at NIR, allow for the possibility to create ultra-sensitive and long-range sensing networks to be deployed in a variety of both biological and chemical sensors. This work provides a detailed review of the key science underpinning such systems as well as recent progress in the development of several LSPR-based biosensors in the NIR wavelengths, including an overview of the LSPR phenomena along recent developments in the field of nanomaterials and nanostructure development towards NIR sensing. The review ends with a consideration of key advances in terms of nanostructure characteristics for LSPR sensing and prospects for future research and advances in this field.
表面等离子体共振（SPR）和局域表面等离子体共振（LSPR）是当今最常见且强大的基于无标记折射率的生物传感技术。聚焦于LSPR传感器，其性能高度依赖于所采用纳米材料的尺寸、形状和性质。事实上，对这些参数的调整能够开发出在紫外（UV）和近红外（NIR）之间具有可调波长范围的LSPR传感器。此外，将LSPR与光纤技术相结合，因其在近红外波段具有低衰减系数，使得创建超灵敏且远程的传感网络成为可能，这些网络可部署在各种生物和化学传感器中。本文详细综述了支撑此类系统的关键科学原理，以及近红外波长下几种基于LSPR的生物传感器开发的最新进展，包括对LSPR现象以及纳米材料和纳米结构开发领域朝着近红外传感方向的最新进展的概述。综述最后考虑了LSPR传感在纳米结构特性方面的关键进展以及该领域未来研究和进展的前景。
