Tian Cong, Tang Zhe, Hou Yike, Mushtaq Asim, Naz Shafaq, Yu Zhangsen, Farheen Jabeen, Iqbal Muhammad Zubair, Kong Xiangdong
Institute of Smart Biomedical Materials, School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Zhejiang-Mauritius Joint Research Center for Biomaterials and Tissue Engineering, Hangzhou 310018, China.
Nanomaterials (Basel). 2022 Apr 16;12(8):1370. doi: 10.3390/nano12081370.
Significant attention is paid to the design of magnetoplasmonic nanohybrids, which exploit synergistic properties for biomedical applications. Here, a facile method was employed to prepare plasmonic magnetic Au-MnO heterostructured hybrid nanoparticles for imaging-guided photothermal therapy of cancers in vitro, with the view to reducing the serious drawbacks of chemotherapy and gadolinium-based contrast agents. The biocompatibility of the prepared Au-MnO nanocomposites was further enhanced by Food and Drug Administration (FDA)-approved triblock copolymers Pluronic F-127 and chitosan oligosaccharide (COS), with complementary support to enhance the absorption in the near-infrared (NIR) region. In addition, synthesized COS-PF127@Au-MnO nanocomposites exhibited promising contrast enhancement in T MR imaging with a good r relaxivity value (1.2 mM s), demonstrating a capable substitute to Gd-based toxic contrast agents. In addition, prepared COS-PF127@Au-MnO hybrid nanoparticles (HNPs) produced sufficient heat (62 °C at 200 μg/mL) to ablate cancerous cells upon 808 nm laser irradiation, inducing cell toxicity, and apoptosis. The promising diagnostic and photothermal therapeutic performance demonstrated the appropriateness of the COS-PF127@Au-MnO HNPs as a potential theranostic agent.
磁等离子体纳米杂化物的设计受到了广泛关注，这类杂化物利用协同特性用于生物医学应用。在此，我们采用一种简便方法制备了用于体外癌症成像引导光热治疗的等离子体磁性金-二氧化锰异质结构混合纳米颗粒，旨在减少化疗和基于钆的造影剂的严重缺点。通过美国食品药品监督管理局（FDA）批准的三嵌段共聚物普朗尼克F-127和壳寡糖（COS）进一步提高了所制备的金-二氧化锰纳米复合材料的生物相容性，并在近红外（NIR）区域提供互补支持以增强吸收。此外，合成的COS-PF127@Au-MnO纳米复合材料在T磁共振成像中表现出有前景的对比度增强，具有良好的r弛豫率值（1.2 mM s），证明是基于钆的有毒造影剂的有效替代品。此外，制备的COS-PF127@Au-MnO混合纳米颗粒（HNPs）在808 nm激光照射下产生足够的热量（200 μg/mL时为62°C）以消融癌细胞，诱导细胞毒性和凋亡。其有前景的诊断和光热治疗性能证明了COS-PF127@Au-MnO HNPs作为潜在诊疗剂的适用性。
