Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 40530 Gothenburg, Sweden.
Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, 40530 Gothenburg, Sweden.
Int J Mol Sci. 2021 Mar 9;22(5):2750. doi: 10.3390/ijms22052750.
Diminished lymphatic function and abnormal morphology are common in chronic inflammatory diseases. Recent studies are investigating whether it is possible to target chronic inflammation by promoting resolution of inflammation, in order to enhance lymphatic function and attenuate disease. Resolution of inflammation is an active process regulated by bioactive lipids known as specialized pro-resolving mediators (SPMs). SPMs can modulate leukocyte migration and function, alter cytokine/chemokine release, modify autophagy, among other immune-related activities. Here, we summarize the role of the lymphatics in resolution of inflammation and lymphatic impairment in chronic inflammatory diseases. Furthermore, we discuss the current literature describing the connection between SPMs and the lymphatics, and the possibility of targeting the lymphatics with innovative SPM therapy to promote resolution of inflammation and mitigate disease.
淋巴功能减弱和形态异常在慢性炎症性疾病中很常见。最近的研究正在探讨是否有可能通过促进炎症消退来靶向慢性炎症，以增强淋巴功能并减轻疾病。炎症消退是一个由生物活性脂质调节的主动过程，这些脂质被称为专门的促解决介质（SPM）。SPM 可以调节白细胞的迁移和功能，改变细胞因子/趋化因子的释放，改变自噬等免疫相关活动。在这里，我们总结了淋巴管在炎症消退和慢性炎症性疾病中淋巴管损伤中的作用。此外，我们还讨论了目前描述 SPM 与淋巴管之间联系的文献，并探讨了用创新的 SPM 疗法靶向淋巴管以促进炎症消退和减轻疾病的可能性。
