温度对不同脑区薄片耗氧量的影响。

Effects of temperature on the oxygen consumption in thin slices from different brain regions.

作者信息

Nishizaki T, Yamauchi R, Tanimoto M, Okada Y

机构信息

Department of Physiology, Kobe University School of Medicine, Japan.

出版信息

Neurosci Lett. 1988 Apr 12;86(3):301-5. doi: 10.1016/0304-3940(88)90500-9.

DOI:10.1016/0304-3940(88)90500-9

PMID:3380322

Abstract

The oxygen consumption of brain slices from 12 different regions of the guinea pig brain was measured and the effects of temperature on the consumption was investigated. At 37 degrees C the oxygen consumption in cerebral gray matter and inferior colliculus was higher than that of other regions, whilst the consumption in cerebral white matter and brainstem was approximately half of that in cerebral gray matter. In any region lowering the tissue temperature from 37 to 28 degrees C reduced the oxygen consumption by 6-8% of the value obtained at 37 degrees C per one degree. At 21 degrees C the consumption was decreased to 15% of the value obtained at 37 degrees C. It is notable that the consumption in hippocampal slices tested was remarkably increased by raising the temperature up to 50 degrees C and no consumption was observed at 55 degrees C.

摘要

测量了豚鼠大脑12个不同区域脑片的氧消耗量，并研究了温度对氧消耗的影响。在37℃时，脑灰质和下丘的氧消耗量高于其他区域，而脑白质和脑干的氧消耗量约为脑灰质的一半。在任何区域，将组织温度从37℃降至28℃，每降低1℃，氧消耗量就会降低在37℃时所测得值的6 - 8%。在21℃时，氧消耗量降至在37℃时所测得值的15%。值得注意的是，测试的海马体脑片的氧消耗量在温度升至50℃时显著增加，而在55℃时未观察到氧消耗。