Bagińska Natalia, Cieślik Martyna, Górski Andrzej, Jończyk-Matysiak Ewa
Bacteriophage Laboratory, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wrocław, Poland.
Phage Therapy Unit, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wrocław, Poland.
Antibiotics (Basel). 2021 Mar 9;10(3):281. doi: 10.3390/antibiotics10030281.
are bacteria that belong to the critical priority group due to their carbapenems and third generation cephalosporins resistance, which are last-chance antibiotics. The growing multi-drug resistance and the ability of these bacteria to form biofilms makes it difficult to treat infections caused by this species, which often affects people with immunodeficiency or intensive care unit patients. In addition, most of the infections are associated with catheterization of patients. These bacteria are causative agents, inter alia, of urinary tract infections (UTI) which can cause serious medical and social problems, because of treatment difficulties as well as the possibility of recurrence and thus severely decrease patients' quality of life. Therefore, a promising alternative to standard antibiotic therapy can be bacteriophage therapy, which will generate lower costs and will be safer for the treated patients and has real potential to be much more effective. The aim of the review is to outline the important role of drug-resistant in the pathogenesis of UTI and highlight the potential for fighting these infections with bacteriophage therapy. Further studies on the use of bacteriophages in the treatment of UTIs in animal models may lead to the use of bacteriophage therapy in human urinary tract infections caused by in the future.
是由于对碳青霉烯类和第三代头孢菌素耐药而属于关键优先组的细菌，这些是最后一线抗生素。这些细菌不断增加的多药耐药性以及形成生物膜的能力使得治疗由该菌种引起的感染变得困难，这类感染常常影响免疫缺陷患者或重症监护病房患者。此外，大多数感染与患者的导管插入术有关。这些细菌尤其是尿路感染（UTI）的病原体，由于治疗困难以及复发的可能性，会导致严重的医学和社会问题，从而严重降低患者的生活质量。因此，噬菌体疗法可能是标准抗生素治疗的一种有前景的替代方法，它将降低成本，对接受治疗的患者更安全，并且确实有可能更有效。本综述的目的是概述耐药菌在尿路感染发病机制中的重要作用，并强调用噬菌体疗法对抗这些感染的潜力。未来在动物模型中进一步研究噬菌体在治疗尿路感染中的应用可能会导致噬菌体疗法用于治疗由引起的人类尿路感染。
