人类尸检下丘脑含胱抑素C的神经元。

Cystatin C containing neurons in human postmortem hypothalamus.

作者信息

Bernstein H G, Järvinen M, Pöllänen R, Schirpe H, Knöfel B, Rinne R

机构信息

Institute of Anatomy, Medical Academy, Magdeburg, G.D.R.

出版信息

Neurosci Lett. 1988 May 26;88(2):131-4. doi: 10.1016/0304-3940(88)90113-9.

DOI:10.1016/0304-3940(88)90113-9

PMID:3380352

Abstract

The regional distribution and cellular localization of cystatin C in neurons of human postmortem hypothalamic was studied by use of peroxidase-anti-peroxidase technique. Cystatin C (earlier named gamma-trace) was found to be present in multiple nerve cells belonging to nuclei supraopticus, paraventricularis and arcuatus. We speculate that the occurrence of cystatin C in human cerebrospinal fluid is the result of a release of the protein from these neurons into the ventricular system.

摘要

运用过氧化物酶-抗过氧化物酶技术，研究了胱抑素C在人死后下丘脑神经元中的区域分布及细胞定位。胱抑素C（早期称为γ-痕量蛋白）存在于视上核、室旁核和弓状核的多个神经细胞中。我们推测，人脑脊液中胱抑素C的出现是该蛋白从这些神经元释放到脑室系统的结果。