Skolkovo Institute of Science and Technology, Bolshoy Boulevard 30b1, 121205 Moscow, Russia.
Department of Chemistry, Lomonosov Moscow State University, 119992 Moscow, Russia.
Int J Mol Sci. 2021 Mar 15;22(6):2984. doi: 10.3390/ijms22062984.
The progress of the cell cycle is directly regulated by modulation of cyclins and cyclin-dependent kinases. However, many proteins that control DNA replication, RNA transcription and the synthesis and degradation of proteins can manage the activity or levels of master cell cycle regulators. Among them, RNA helicases are key participants in RNA metabolism involved in the global or specific tuning of cell cycle regulators at the level of transcription and translation. Several RNA helicases have been recently evaluated as promising therapeutic targets, including eIF4A, DDX3 and DDX5. However, targeting RNA helicases can result in side effects due to the influence on the cell cycle. In this review, we discuss direct and indirect participation of RNA helicases in the regulation of the cell cycle in order to draw attention to downstream events that may occur after suppression or inhibition of RNA helicases.
细胞周期的进程直接受到细胞周期蛋白和细胞周期蛋白依赖性激酶的调节。然而，许多控制 DNA 复制、RNA 转录以及蛋白质合成和降解的蛋白质可以调节主细胞周期调节剂的活性或水平。其中，RNA 解旋酶是参与 RNA 代谢的关键参与者，可在转录和翻译水平上对细胞周期调节剂进行全局或特定调节。最近，几种 RNA 解旋酶已被评估为有前途的治疗靶点，包括 eIF4A、DDX3 和 DDX5。然而，由于对细胞周期的影响，靶向 RNA 解旋酶可能会产生副作用。在这篇综述中，我们讨论了 RNA 解旋酶在细胞周期调控中的直接和间接参与，以引起对抑制或抑制 RNA 解旋酶后可能发生的下游事件的关注。
