Flisiak-Jackiewicz Marta, Bobrus-Chociej Anna, Wasilewska Natalia, Lebensztejn Dariusz Marek
Department of Pediatrics, Gastroenterology, Hepatology, Nutrition and Allergology, Medical University of Bialystok, 15-274 Bialystok, Poland.
J Clin Med. 2021 Mar 1;10(5):924. doi: 10.3390/jcm10050924.
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the world, which predispose to more serious hepatic conditions. It ranges from simple liver steatosis to nonalcoholic steatohepatitis (NASH), which may progress to cirrhosis, and even end-stage liver disease. Since obesity became one of the most important health concerns wordwide, a considerable increase in the prevalance of NAFLD and other metabolic implications has been observed, both in adults and children. Due to the coexistence of visceral obesity, insulin resistance, dyslipidemia, NAFLD is considered to be the hepatic manifestation of metabolic syndrome (MetS). These relationships between NAFLD and MetS led to the set up in adults of a new term combining both of these conditions, called metabolic dysfunction-associated fatty liver disease (MAFLD). Based on these findings, we propose a set of criteria, which may be useful to diagnose MAFLD in children and adolescents.
非酒精性脂肪性肝病（NAFLD）是全球最常见的慢性肝病，易引发更严重的肝脏疾病。其范围从单纯性肝脂肪变性到非酒精性脂肪性肝炎（NASH），后者可能进展为肝硬化，甚至终末期肝病。自从肥胖成为全球最重要的健康问题之一以来，在成人和儿童中，NAFLD的患病率以及其他代谢影响都有了显著增加。由于内脏肥胖、胰岛素抵抗、血脂异常并存，NAFLD被认为是代谢综合征（MetS）的肝脏表现。NAFLD与MetS之间的这些关系导致在成人中设立了一个结合这两种情况的新术语，称为代谢功能障碍相关脂肪性肝病（MAFLD）。基于这些发现，我们提出了一套标准，可能有助于诊断儿童和青少年的MAFLD。
