Han Jung Yeob, Lee Hun, Chung Jae Lim, Kim Young Jun, Kim Jae Yong, Tchah Hungwon
Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
Eyejun Ophthalmic Clinic, Seoul 06232, Korea.
J Clin Med. 2021 Mar 1;10(5):960. doi: 10.3390/jcm10050960.
We aimed to investigate the immunoglobulin E (IgE) detection rate and allergen patterns in patients with isolated allergic conjunctivitis using the multiple allergen simultaneous test (MAST)-immunoblot assay. A total of 120 patients with allergic conjunctivitis and no associated rhinitis, asthma, or dermatitis underwent the MAST-immunoblot assay to measure serum total IgE (TIgE) and serum specific IgE (SIgE) against 57 allergens. Patients were classified into subgroups based on the season when the eye symptoms were exacerbated, and TIgE and SIgE positivity. Differences between sex and age groups were also analyzed. Of the 120 patients, 57.5% (69 patients) and 69.2% (83 patients) were positive for TIgE (≥100 IU/mL) and SIgE (≥0.7 IU/mL), respectively. The allergens that most frequently triggered sensitization in the study population were , , , , and house dust. House dust mites, such as and , showed the highest detection rates regardless of the season. Men had a higher positive rate for TIgE than women, whereas a higher rate of sensitization, detected as SIgE positivity, was seen in younger patients. In conclusion, MAST-immunoblot assay can detect sensitizing allergens in patients with isolated allergic conjunctivitis.
我们旨在使用多过敏原同步检测（MAST）免疫印迹法，调查单纯性过敏性结膜炎患者的免疫球蛋白E（IgE）检测率和过敏原模式。共有120例患有过敏性结膜炎且无相关鼻炎、哮喘或皮炎的患者接受了MAST免疫印迹法检测，以测量血清总IgE（TIgE）和针对57种过敏原的血清特异性IgE（SIgE）。根据眼部症状加重的季节以及TIgE和SIgE阳性情况，将患者分为亚组。还分析了性别和年龄组之间的差异。在120例患者中，TIgE（≥100 IU/mL）和SIgE（≥0.7 IU/mL）阳性的患者分别为57.5%（69例）和69.2%（83例）。在研究人群中最常引发致敏的过敏原是 、 、 、 和屋尘。无论季节如何，屋尘螨，如 和 ，检测率最高。男性TIgE阳性率高于女性，而在年轻患者中，以SIgE阳性检测到的致敏率更高。总之，MAST免疫印迹法可检测单纯性过敏性结膜炎患者中的致敏过敏原。
