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脱脂牛奶作为植物药产品的应用:对过敏人群是否有风险?

Skimmed Milk Applied as a Phytopharmaceutical Product: A Risk for Allergic Populations?

机构信息

Center for Public Health and Primary Care Medicine (Unisanté), University of Lausanne, 1011 Lausanne, Switzerland.

Public Health Service, Vaud Canton, 1014 Lausanne, Switzerland.

出版信息

Int J Environ Res Public Health. 2021 Mar 1;18(5):2400. doi: 10.3390/ijerph18052400.

DOI:10.3390/ijerph18052400
PMID:33804540
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7967751/
Abstract

Milk allergy is among the most common food-related allergies. Milk-based products are recognized as plant protection products (PPPs) in several countries as alternatives to synthetic pesticides. The potential health risk for allergic workers, as well as the general population, is yet to be assessed. An investigation was conducted in the Vaud Canton of Switzerland, where milk-based products are sprayed by helicopter over vineyards. Air lactose concentration was measured at 14 locations via 25 mm IOM Multidust samplers. Residual lactose concentration was measured on the surface of leaves over 7 days following spraying. Surface contamination downwind from the treated area was estimated through computer-based modeling using AgDRIFT software. The average milk protein concentration inside and outside the vineyard was 0.47 and 0.16 µg/m, respectively. Milk residues persisted on the leaf surface for an average of three days. Modelling results revealed an estimated order of magnitude of 0.1-0.5 µg/m in milk proteins within one hour after the treatment in the close vicinity of the treated area. Our results reveal that the potential exposure to milk proteins in and around helicopter-treated vineyards is not negligible and that prevention messages targeted to individuals with severe allergies should be considered.

摘要

牛奶过敏是最常见的食物相关过敏之一。在几个国家,牛奶制品被视为植物保护产品(PPPs),可作为合成农药的替代品。对于过敏工人以及普通人群,其潜在健康风险尚未得到评估。瑞士沃州进行了一项调查,在该州,直升机向葡萄园喷洒牛奶制品。通过 25 毫米 IOM Multidust 采样器在 14 个地点测量空气中的乳糖浓度。在喷洒后 7 天内,测量叶片表面的残留乳糖浓度。通过使用 AgDRIFT 软件的基于计算机的建模来估算下风处的表面污染。葡萄园内外的平均牛奶蛋白浓度分别为 0.47 和 0.16 µg/m。牛奶残留物在叶片表面平均持续三天。建模结果显示,在处理区域附近一小时内,处理后空气中的牛奶蛋白浓度估计为 0.1-0.5 µg/m。我们的结果表明,直升机处理的葡萄园内外的牛奶蛋白潜在暴露量不容忽视,应考虑针对严重过敏人群的预防信息。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06ae/7967751/a18c89951b78/ijerph-18-02400-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06ae/7967751/ab6c6c89da3b/ijerph-18-02400-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06ae/7967751/cd93ba9e58f7/ijerph-18-02400-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06ae/7967751/1a9f14d1055c/ijerph-18-02400-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06ae/7967751/27c690fae364/ijerph-18-02400-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06ae/7967751/a18c89951b78/ijerph-18-02400-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06ae/7967751/ab6c6c89da3b/ijerph-18-02400-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06ae/7967751/cd93ba9e58f7/ijerph-18-02400-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06ae/7967751/1a9f14d1055c/ijerph-18-02400-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06ae/7967751/27c690fae364/ijerph-18-02400-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06ae/7967751/a18c89951b78/ijerph-18-02400-g005.jpg

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本文引用的文献

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Are Physicochemical Properties Shaping the Allergenic Potency of Animal Allergens?物理化学性质是否在塑造动物过敏原的致敏效力?
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Bovine Milk Allergens: A Comprehensive Review.牛乳过敏原:全面综述
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