Department of Pharmacology, Chitkara College of Pharmacy, Chitkara University, Punjab 140401, India.
Department of Biology, Faculty of Science, Selcuk University Campus, Konya 42130, Turkey.
Int J Mol Sci. 2021 Mar 20;22(6):3179. doi: 10.3390/ijms22063179.
Obesity or overweight are not superficial problems, constituting a pressing issue. The obesity index has almost tripled since 1975, which is an alarming state. Most of the individuals are currently becoming overweight or have inappropriate body mass index (BMI) conditions. Obesity is characterized by increased fat accumulation and thus poses a higher health risk. There is increased size and volume of fat cells in the body, which usually accounts for obesity. Many investigations have been carried out in this area, such as behavioral improvements, dietary changes, chemical involvements, etc., but presently no such goals are established to manage these health concerns. Based on previous literature reports and our interpretation, the current review indicates the involvement of various transcriptional and transporter functions in modifying the above-mentioned health conditions. Various transcriptional factors such as Forkhead box O1 (FoxO1) impart a significant effect on the physiology and pathology of metabolic dysfunction such as obesity. FoxO1 plays a dual role whether in the progression or suppression of metabolic processes depending on its targets. Thus, in the current study, will be discussed the dual role of FoxO1 in metabolic conditions (such as obesity), also summarizing the role of various other transcriptional factors involved in obesity.
肥胖或超重不是表面问题，而是构成紧迫问题。自 1975 年以来，肥胖指数几乎翻了三倍，这令人震惊。目前大多数人超重或身体质量指数（BMI）不当。肥胖的特征是脂肪积累增加，因此健康风险更高。体内脂肪细胞的大小和体积增加，这通常是肥胖的原因。在这一领域已经进行了许多研究，如行为改善、饮食变化、化学干预等，但目前尚未确立任何目标来管理这些健康问题。根据以前的文献报道和我们的解释，本综述表明各种转录和转运体功能参与了上述健康状况的改变。各种转录因子，如叉头框 O1（FoxO1），对代谢功能障碍（如肥胖）的生理学和病理学有重要影响。FoxO1 根据其靶标在代谢过程的进展或抑制中发挥双重作用。因此，在本研究中，将讨论 FoxO1 在代谢状况（如肥胖）中的双重作用，并总结涉及肥胖的其他各种转录因子的作用。
