Kauma S, Clark M R, White C, Halme J
Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill.
Obstet Gynecol. 1988 Jul;72(1):13-8.
Fibronectin, a known growth factor for fibroblasts, is produced by alveolar macrophages from patients with interstitial pulmonary fibrosis. Because peritoneal macrophages have been implicated in the disease process of endometriosis, we measured the production of fibronectin by peritoneal macrophages in vitro and the concentration of fibronectin in peritoneal fluid samples. Twenty-nine patients had a normal pelvis, 22 had endometriosis, and 14 had tubal occlusion and/or adhesions. Human peritoneal macrophages demonstrated de novo synthesis of fibronectin. The peritoneal macrophage fibronectin was detected by an enzyme-linked immunosorbent assay for serum fibronectin. Peritoneal macrophages from patients with endometriosis produced approximately three times the amount of fibronectin as normal patients or patients with tubal occlusion and/or adhesions (P less than or equal to .01 and P less than or equal to .02, respectively). The mean peritoneal fluid concentration of fibronectin, however, was about 30% lower in patients with endometriosis than in normal patients (P less than or equal to .02). We suggest that increased peritoneal macrophage fibronectin production in patients with endometriosis may contribute to the adhesion formation and associated reactive fibrosis seen in this disease, and may also influence the implantation of endometrial cells and their subsequent growth in the pelvis.
纤连蛋白是一种已知的成纤维细胞生长因子，由间质性肺纤维化患者的肺泡巨噬细胞产生。由于腹膜巨噬细胞与子宫内膜异位症的发病过程有关，我们在体外测量了腹膜巨噬细胞产生纤连蛋白的情况以及腹膜液样本中纤连蛋白的浓度。29例患者盆腔正常，22例患有子宫内膜异位症，14例患有输卵管阻塞和/或粘连。人腹膜巨噬细胞可从头合成纤连蛋白。通过检测血清纤连蛋白的酶联免疫吸附测定法来检测腹膜巨噬细胞纤连蛋白。子宫内膜异位症患者的腹膜巨噬细胞产生的纤连蛋白量约为正常患者或输卵管阻塞和/或粘连患者的三倍（分别为P≤0.01和P≤0.02）。然而，子宫内膜异位症患者腹膜液中纤连蛋白的平均浓度比正常患者低约30%（P≤0.02）。我们认为，子宫内膜异位症患者腹膜巨噬细胞产生纤连蛋白增加可能有助于该疾病中出现的粘连形成和相关的反应性纤维化，也可能影响子宫内膜细胞在盆腔中的植入及其随后的生长。
