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4D多普勒超声在高级别浆液性卵巢癌血管评估中的应用——初步研究

4D Doppler Ultrasound in High Grade Serous Ovarian Cancer Vascularity Evaluation-Preliminary Study.

作者信息

Kudla Marek Jerzy, Zikan Michal, Fischerova Daniela, Stolecki Mateusz, Alcazar Juan Luis

机构信息

Department of Perinatology and Oncological Gynecology, Faculty of Medical Sciences, Medical University of Silesia, Medyków 14, 40-752 Katowice, Poland.

Department of Gynecology and Obstetrics, Charles University-First Faculty of Medicine and Bulovka University Hospital, Budinova 67/2, 181 00 Prague, Czech Republic.

出版信息

Diagnostics (Basel). 2021 Mar 24;11(4):582. doi: 10.3390/diagnostics11040582.

DOI:10.3390/diagnostics11040582
PMID:33805053
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8064103/
Abstract

The aim of the study was to evaluate the usefulness of 4D Power Doppler tissue evaluation to discriminate between normal ovaries and ovarian cancer tumors. This was a prospective observational study. Twenty-three cases of surgically confirmed ovarian High Grade Serous Carcinoma (HGSC) were analyzed. The control group consisted of 23 healthy patients, each matching their study-group counterpart age wise (±3 years) and according to their menopausal status. Transvaginal Doppler 4D ultrasound scans were done on every patient and analyzed with 3D/4D software. Two 4D indices-volumetric Systolic/Diastolic Index (vS/D) and volumetric Pulsatility Index (vPI)-were calculated. To keep results standardized and due to technical limitations, virtual 1cc spherical tissue samples taken from the part with highest vascularization as detected by bi-directional Power Doppler were analyzed for both groups of ovaries. Values of volumetric S/D indices and volumetric PI indices were statistically lower in ovarian malignant tumors compared to normal ovaries: 1.096 vs. 1.794 and 0.092 vs. 0.558, respectively ( < 0.001). The 4D bi-directional Power Doppler vascular indices were statistically different between malignant tumors and normal ovaries. These findings could support the rationale for future studies for assessing this technology to discriminate between malignant and benign tumors.

摘要

本研究的目的是评估四维能量多普勒组织评估在鉴别正常卵巢和卵巢癌肿瘤方面的效用。这是一项前瞻性观察性研究。分析了23例经手术确诊的卵巢高级别浆液性癌（HGSC）病例。对照组由23名健康患者组成，每组在年龄（±3岁）和绝经状态方面与研究组对应患者相匹配。对每位患者进行经阴道多普勒四维超声扫描，并使用三维/四维软件进行分析。计算了两个四维指标——容积收缩/舒张指数（vS/D）和容积搏动指数（vPI）。为使结果标准化且由于技术限制，对两组卵巢均分析了从双向能量多普勒检测到的血管化程度最高的部位获取的虚拟1立方厘米球形组织样本。与正常卵巢相比，卵巢恶性肿瘤的容积S/D指数和容积PI指数值在统计学上较低：分别为1.096对1.794和0.092对0.558（<0.001）。恶性肿瘤和正常卵巢之间的四维双向能量多普勒血管指数在统计学上存在差异。这些发现可为未来评估该技术鉴别恶性和良性肿瘤的研究提供理论依据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95d6/8064103/6bcb8f5d02aa/diagnostics-11-00582-g012.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95d6/8064103/6bcb8f5d02aa/diagnostics-11-00582-g012.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95d6/8064103/b57b9f9bda8b/diagnostics-11-00582-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95d6/8064103/bd85d7a5c9de/diagnostics-11-00582-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95d6/8064103/ef36a21cabec/diagnostics-11-00582-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95d6/8064103/a6372fdbdc32/diagnostics-11-00582-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95d6/8064103/a186e56df3aa/diagnostics-11-00582-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95d6/8064103/008b46f0b742/diagnostics-11-00582-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95d6/8064103/5094295a0b6a/diagnostics-11-00582-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95d6/8064103/28b2439596a1/diagnostics-11-00582-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95d6/8064103/21b08298a635/diagnostics-11-00582-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95d6/8064103/6bcb8f5d02aa/diagnostics-11-00582-g012.jpg

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