Department of Orthopedics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Department of Orthopedics, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung 812, Taiwan.
Int J Environ Res Public Health. 2021 Mar 25;18(7):3390. doi: 10.3390/ijerph18073390.
Several studies have reported that Hemoglobin A1c (HbA1c) levels increase with age for people without diabetes. However, HbA1c levels associated with age and gender have not been well investigated for Taiwanese adults. The objective of this study was to investigate the sex-specific association between HbA1c levels and age for Taiwanese adults without diabetes. The data were collected from the Taiwan Biobank database with inclusive criteria being participants without diabetes. The association between HbA1c values and age was conducted by linear regression analysis, HbA1c values between sexes were compared by two-sample -test, and HbA1c levels among age groups were compared using one-way ANOVA. The results showed that HbA1c levels were positively correlated with age, and the levels for males were significantly higher than for females among all participants. However, there was no significantly positive correlation between HbA1c levels and age in males for age group of 50-70 years. The levels of males were significantly higher than females for age groups of 30-39 and 40-49 years. There were significant differences in HbA1c levels among age groups for all participants, males, and females except for the two age groups of 50-59 and 60-70 years in males. Age and gender were important factors affecting HbA1c levels. Our results suggested that the HbA1c cut-point levels for the diagnosis of diabetes should vary by age and gender.
几项研究报告称，无糖尿病的人群血红蛋白 A1c（HbA1c）水平随年龄增长而升高。然而，对于台湾成年人，尚未充分研究与年龄和性别相关的 HbA1c 水平。本研究旨在调查无糖尿病的台湾成年人中 HbA1c 水平与年龄的性别特异性关联。数据来自台湾生物库数据库，纳入标准为无糖尿病的参与者。通过线性回归分析进行 HbA1c 值与年龄之间的关联，通过两样本 t 检验比较男女之间的 HbA1c 值，通过单向方差分析比较各年龄组之间的 HbA1c 水平。结果表明，HbA1c 水平与年龄呈正相关，所有参与者中男性的 HbA1c 水平明显高于女性。然而，在 50-70 岁年龄组的男性中，HbA1c 水平与年龄之间没有明显的正相关关系。在 30-39 岁和 40-49 岁年龄组中，男性的 HbA1c 水平明显高于女性。除了男性的 50-59 和 60-70 岁两个年龄组外，所有参与者、男性和女性的 HbA1c 水平在各年龄组之间均存在显著差异。年龄和性别是影响 HbA1c 水平的重要因素。我们的结果表明，用于诊断糖尿病的 HbA1c 切点水平应因年龄和性别而异。
