Ahmed Sumia F, Hassan Ahmed A, Eltayeb Majdolin M, Omar Saeed M, Adam Ishag
Biochemistry Department, Faculty of Medicine, Najran University, Najran 664621, Saudi Arabia.
Faculty of Medicine, University of Khartoum, Khartoum P.O. Box 102, Sudan.
Life (Basel). 2023 Oct 5;13(10):2017. doi: 10.3390/life13102017.
The level of association between glycated hemoglobin (HbA1c) level and ethnicity, age, and gender is not yet settled. This study aimed to investigate the association between ethnicity, age, and gender and HbA1c level among adults who were known not to have diabetes mellitus in northern and eastern Sudan.
A comparative community-based cross-sectional study was conducted. Sociodemographic and clinical characteristics data were collected. HbA1c levels were measured, and multiple linear regression analysis was performed.
A total of 898 adults (363 in northern Sudan and 535 in eastern Sudan) were included; 349 (38.9%) were males. The HbA1c level was significantly higher in eastern Sudan, and there was no significant difference in HbA1c levels between genders. In multiple linear regression, for adults with HbA1c <6.5%, ethnicity and BMI were associated with HbA1c, but age and gender were not associated with HbA1c. In northern Sudan, age was positively associated with HbA1c, and there was no association between gender, BMI, and HbA1c in adults with HbA1c <6.5%. In eastern Sudan, BMI was positively associated with HbA1c, and there was no significant association between age and gender and HbA1c level in adults with HbA1c <6.5%.
HbA1c levels are influenced by ethnicity and age but not by gender.
糖化血红蛋白（HbA1c）水平与种族、年龄和性别的关联程度尚未确定。本研究旨在调查苏丹北部和东部已知无糖尿病的成年人中，种族、年龄和性别与HbA1c水平之间的关联。
进行了一项基于社区的比较横断面研究。收集了社会人口统计学和临床特征数据。测量了HbA1c水平，并进行了多元线性回归分析。
共纳入898名成年人（苏丹北部363名，苏丹东部535名）；349名（38.9%）为男性。苏丹东部的HbA1c水平显著更高，且性别之间的HbA1c水平无显著差异。在多元线性回归中，对于HbA1c<6.5%的成年人，种族和体重指数与HbA1c相关，但年龄和性别与HbA1c无关。在苏丹北部，年龄与HbA1c呈正相关，在HbA1c<6.5%的成年人中，性别、体重指数与HbA1c之间无关联。在苏丹东部，体重指数与HbA1c呈正相关，在HbA1c<6.5%的成年人中，年龄、性别与HbA1c水平无显著关联。
HbA1c水平受种族和年龄影响，但不受性别影响。
