Tung Keith T S, Wong Rosa S, Tsang Hing Wai, Chan Bianca N K, Wong Siew Yan, So Hung-Kwan, Tung Joanna Y L, Ho Marco H K, Wong Wilfred H S, Ip Patrick
Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong SAR 000000, China.
Department of Paediatrics, Hong Kong Children's Hospital, Hong Kong 000000 SAR, China.
Nutrients. 2021 Mar 25;13(4):1068. doi: 10.3390/nu13041068.
Recent evidence suggests that breastfeeding may increase the risk of vitamin D deficiency in offspring. However, it is unclear whether increased risk results from breastfeeding alone, or whether it is associated together with other risk factors. This study surveyed 208 infant-mother dyads recruited by stratified random sampling in different districts of Hong Kong. Mothers were asked to complete a questionnaire on their demographics, history of risk behavior, and feeding practices. Peripheral blood samples were collected from infants to determine their vitamin D status. Among all infant participants, 70 were vitamin D insufficient or deficient. Being breastfed, being a girl, having a multiparous mother, and the use of sun cream were found to be the strongest risk factors for vitamin D insufficiency during infancy (all < 0.05), after mutual adjustment. The cumulative risk model displayed a dose-response pattern between the number of risk factors and the risk of vitamin D insufficiency during this period. Our findings indicate the risk profile of infants with insufficient vitamin D. Guidelines and recommendations on healthy diet and lifestyle should be provided to mothers during the early stage of pregnancy to increase the likelihood of adequate levels of vitamin D in their offspring.
近期证据表明，母乳喂养可能会增加后代维生素D缺乏的风险。然而，尚不清楚风险增加是仅由母乳喂养导致，还是与其他风险因素共同作用的结果。本研究对通过分层随机抽样在香港不同地区招募的208对母婴进行了调查。母亲们被要求填写一份关于其人口统计学、风险行为史和喂养方式的问卷。采集婴儿的外周血样本以确定其维生素D状况。在所有参与研究的婴儿中，70名婴儿维生素D不足或缺乏。经相互调整后发现，母乳喂养、为女孩、母亲多产以及使用防晒霜是婴儿期维生素D不足的最强风险因素（均P<0.05）。累积风险模型显示，在此期间，风险因素的数量与维生素D不足风险之间存在剂量反应模式。我们的研究结果表明了维生素D不足婴儿的风险特征。应在怀孕早期向母亲提供关于健康饮食和生活方式的指南及建议，以增加其后代维生素D水平充足的可能性。
