Proescholdt Martin A, Schödel Petra, Doenitz Christian, Pukrop Tobias, Höhne Julius, Schmidt Nils Ole, Schebesch Karl-Michael
Department of Neurosurgery, University Hospital Regensburg, 93053 Regensburg, Germany.
Wilhelm Sander Neuro-Oncology Unit, University Hospital Regensburg, 93053 Regensbur, Germany.
Cancers (Basel). 2021 Mar 31;13(7):1616. doi: 10.3390/cancers13071616.
The multidisciplinary management of patients with brain metastases (BM) consists of surgical resection, different radiation treatment modalities, cytotoxic chemotherapy, and targeted molecular treatment. This review presents the current state of neurosurgical technology applied to achieve maximal resection with minimal morbidity as a treatment paradigm in patients with BM. In addition, we discuss the contribution of neurosurgical resection on functional outcome, advanced systemic treatment strategies, and enhanced understanding of the tumor biology.
脑转移瘤（BM）患者的多学科管理包括手术切除、不同的放射治疗方式、细胞毒性化疗和靶向分子治疗。本综述介绍了应用神经外科技术以在发病率最低的情况下实现最大程度切除作为BM患者治疗模式的当前状态。此外，我们还讨论了神经外科切除对功能预后的贡献、先进的全身治疗策略以及对肿瘤生物学的深入理解。
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