Jeste D V, Harris M J, Pearlson G D, Rabins P, Lesser I, Miller B, Coles C, Yassa R
University of California, San Diego.
Psychiatr Clin North Am. 1988 Mar;11(1):1-13.
The authors compared clinical characteristics of 36 late-onset schizophrenic patients from four centers (hospitals in San Diego, Baltimore, Los Angeles, and Montreal). There was a preponderance of the paranoid type with bizarre delusions and auditory hallucinations, chronic course of illness, and response to relatively low doses of neuroleptics. A comparison of late-onset and younger schizophrenic patients revealed both similarities and differences between the two groups. The authors reviewed the relevant literature and discussed the implications for assessing the validity of the concept of late-onset schizophrenia. They believe that, although less common, late-onset schizophrenia is probably as valid an entity (or group of entities) as schizophrenia with onset before age 45.
作者比较了来自四个中心（圣地亚哥、巴尔的摩、洛杉矶和蒙特利尔的医院）的36例晚发性精神分裂症患者的临床特征。这些患者以偏执型为主，伴有怪异的妄想和幻听，病程呈慢性，对相对低剂量的抗精神病药物有反应。晚发性精神分裂症患者与年轻精神分裂症患者的比较显示，两组之间既有相似之处，也有不同之处。作者回顾了相关文献，并讨论了评估晚发性精神分裂症概念有效性的意义。他们认为，尽管晚发性精神分裂症较为少见，但它可能与45岁之前发病的精神分裂症一样，是一个有效的病种（或一组病种）。
