INSERM, U1149, Center of Research on Inflammation, Université de Paris, 75018 Paris, France.
INSERM U1016, Team "Mucosal Microbiota in Chronic Inflammatory Diseases", CNRS UMR 8104, Université de Paris, 75014 Paris, France.
Int J Mol Sci. 2021 Mar 5;22(5):2602. doi: 10.3390/ijms22052602.
Inflammation is a well-characterized critical driver of gastrointestinal cancers. Previous findings have shown that intestinal low-grade inflammation can be promoted by the consumption of select dietary emulsifiers, ubiquitous component of processed foods which alter the composition and function of the gut microbiota. Using a model of colitis-associated cancer, we previously reported that consumption of the dietary emulsifiers carboxymethylcellulose or polysorbate-80 exacerbated colonic tumor development. Here, we investigate the impact of dietary emulsifiers consumption on cancer initiation and progression in a genetical model of intestinal adenomas. In APC mice, we observed that dietary emulsifiers consumption enhanced small-intestine tumor development in a way that appeared to be independent of chronic intestinal inflammation but rather associated with emulsifiers' impact on the proliferative status of the intestinal epithelium as well as on intestinal microbiota composition in both male and female mice. Overall, our findings further support the hypothesis that emulsifier consumption may be a new modifiable risk factor for colorectal cancer (CRC) and that alterations in host-microbiota interactions can favor gastrointestinal carcinogenesis in individuals with a genetical predisposition to such disorders.
炎症是胃肠道癌症的一个重要特征驱动因素。先前的研究结果表明，肠道低度炎症可能会因食用某些选择的膳食乳化剂而加重，这些乳化剂是加工食品中无处不在的成分，可改变肠道微生物群的组成和功能。我们之前在结肠炎相关癌症模型中报告说，食用膳食乳化剂羧甲基纤维素或聚山梨酯 80 会加剧结肠肿瘤的发展。在这里，我们研究了膳食乳化剂的消耗对肠道腺瘤遗传模型中癌症发生和进展的影响。在 APC 小鼠中，我们观察到膳食乳化剂的消耗会增强小肠肿瘤的发展，这种情况似乎与慢性肠道炎症无关，而与乳化剂对肠道上皮细胞增殖状态以及肠道微生物群落组成的影响有关，无论雄性还是雌性小鼠均是如此。总的来说，我们的研究结果进一步支持了这样一种假设，即乳化剂的摄入可能是结直肠癌 (CRC) 的一个新的可改变的风险因素，而宿主-微生物群相互作用的改变可能会促进具有此类疾病遗传易感性的个体的胃肠道癌变。
