Osorio Carolina, Garzón Laura, Jaimes Diego, Silva Edwin, Bustos Rosa-Helena
Evidence-Based Therapeutics Group, Clinical Pharmacology, Universidad de La Sabana, Chía 140013, Colombia.
Faculty of Medicine, University of La Sabana, Chía 140013, Colombia.
Antibiotics (Basel). 2021 Mar 5;10(3):263. doi: 10.3390/antibiotics10030263.
Antimicrobial resistance (AR) is a problem that threatens the search for adequate safe and effective antibiotic therapy against multi-resistant bacteria like methicillin-resistant (MRSA), and vancomycin-resistant (VRE) and , among others. Daptomycin is the treatment of choice for some infections caused by Gram-positive bacteria, indicated most of the time in patients with special clinical conditions where its high pharmacokinetic variability (PK) does not allow adequate plasma concentrations to be reached. The objective of this review is to describe the data available about the type of therapeutic drug monitoring (TDM) method used and described so far in hospitalized patients with daptomycin and to describe its impact on therapeutic success, suppression of bacterial resistance, and control of side effects. The need to create worldwide strategies for the appropriate use of antibiotics is clear, and one of these is the performance of therapeutic drug monitoring (TDM). TDM helps to achieve a dose adjustment and obtain a favorable clinical outcome for patients by measuring plasma concentrations of an administered drug, making a rational interpretation guided by a predefined concentration range, and, thus, adjusting dosages individually.
抗菌药物耐药性（AR）是一个问题，它威胁着针对耐多药细菌（如耐甲氧西林金黄色葡萄球菌（MRSA）、耐万古霉素肠球菌（VRE）等）寻找充分、安全且有效的抗生素治疗方法。达托霉素是治疗某些革兰氏阳性菌引起感染的首选药物，大多数情况下用于有特殊临床状况的患者，这些患者中其高药代动力学变异性（PK）使得无法达到足够的血浆浓度。本综述的目的是描述迄今为止在使用达托霉素的住院患者中所使用和描述的治疗药物监测（TDM）方法类型的数据，并描述其对治疗成功、抑制细菌耐药性以及控制副作用的影响。制定全球范围内合理使用抗生素的策略的必要性是显而易见的，其中之一就是进行治疗药物监测（TDM）。TDM通过测量所给药药物的血浆浓度，在预定义的浓度范围内进行合理的解释，从而调整剂量，有助于实现剂量调整并为患者获得良好的临床结果。
