Bartoloni A, Colao M G, Orsi A, Dei R, Giganti E, Parenti F
Cattedra di Malattie Infettive, Università di Firenze, Italy.
J Antimicrob Chemother. 1990 Nov;26(5):627-33. doi: 10.1093/jac/26.5.627.
The minimum inhibitory concentrations (MICs) of different antibiotics were determined by a broth microdilution method for staphylococci, enterococci and Clostridium difficile. The antimicrobial agents tested were vancomycin, teicoplanin, daptomycin, ramoplanin, MDL 62873, rifampicin and piperacillin, the latter limited to enterococci. In terms of MIC90S, daptomycin (0.89 mg/l). MDL 62873 (0.99 mg/l), and teicoplanin (1.50 mg/l) were found to be highly active against methicillin-resistant Staphylococcus aureus (MRSA). Daptomycin (MIC90 0.48 mg/l), MDL 62873 (0.95 mg/l) and ramoplanin (1.45 mg/l) were the most active drugs against methicillin-resistant S. epidermidis (MRSE). Teicoplanin (MIC90 0.45 mg/l) was the most active agent against enterococci, followed by MDL 62873 (0.65 mg/l) and daptomycin (1.60 mg/l). MDL 62873 gave the lowest MIC90 (0.17 mg/l) for C. difficile. Teicoplanin (MIC90 0.42 mg/l), daptomycin (0.87 mg/l) and ramoplanin (0.98 mg/l) were also very active. Our results indicate that teicoplanin, daptomycin, ramoplanin and MDL 62873, a teicoplanin derivative, are potentially effective alternative antibiotics for treatment of infections caused by staphylococci, enterococci and C. difficile.
采用肉汤微量稀释法测定了不同抗生素对葡萄球菌、肠球菌和艰难梭菌的最低抑菌浓度（MIC）。所测试的抗菌药物有万古霉素、替考拉宁、达托霉素、雷莫拉宁、MDL 62873、利福平及哌拉西林（后者仅用于肠球菌）。就MIC90而言，发现达托霉素（0.89mg/L）、MDL 62873（0.99mg/L）和替考拉宁（1.50mg/L）对耐甲氧西林金黄色葡萄球菌（MRSA）具有高活性。达托霉素（MIC90 0.48mg/L）、MDL 62873（0.95mg/L）和雷莫拉宁（1.45mg/L）是对耐甲氧西林表皮葡萄球菌（MRSE）活性最强的药物。替考拉宁（MIC90 0.45mg/L）是对肠球菌活性最强的药物，其次是MDL 62873（0.65mg/L）和达托霉素（1.60mg/L）。MDL 62873对艰难梭菌的MIC90最低（0.17mg/L）。替考拉宁（MIC90 0.42mg/L）、达托霉素（0.87mg/L）和雷莫拉宁（0.98mg/L）也具有很高活性。我们的结果表明，替考拉宁、达托霉素、雷莫拉宁及替考拉宁衍生物MDL 62873可能是治疗由葡萄球菌、肠球菌和艰难梭菌引起的感染的有效替代抗生素。
