Infection and Immunity Program, Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.
Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, VIC 3800, Australia.
Int J Mol Sci. 2021 Mar 5;22(5):2617. doi: 10.3390/ijms22052617.
T cells represent a critical arm of our immune defense against pathogens. Over the past two decades, considerable inroads have been made in understanding the fundamental principles underpinning the molecular presentation of peptide-based antigens by the Major Histocompatibility Complex molecules (MHC-I and II), and their molecular recognition by specialized subsets of T cells. However, some T cells can recognize lipid-based antigens presented by MHC-I-like molecules that belong to the Cluster of Differentiation 1 (CD1) family. Here, we will review the advances that have been made in the last five years to understand the molecular mechanisms orchestrating the presentation of novel endogenous and exogenous lipid-based antigens by the CD1 glycoproteins and their recognition by specific populations of CD1-reactive T cells.
T 细胞是我们对抗病原体的免疫防御的重要组成部分。在过去的二十年中，人们在理解主要组织相容性复合体分子（MHC-I 和 II）对基于肽的抗原的分子呈递的基本原理及其与专门的 T 细胞亚群的分子识别方面取得了相当大的进展。然而，一些 T 细胞可以识别由属于分化群 1（CD1）家族的 MHC-I 样分子呈递的脂类抗原。在这里，我们将回顾过去五年在理解 CD1 糖蛋白呈递新型内源性和外源性脂类抗原的分子机制以及特定群体的 CD1 反应性 T 细胞识别这些抗原的分子机制方面取得的进展。
