School of Pharmacy, University of Camerino, 62032 Camerino, Italy.
Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, 04103 Leipzig, Germany.
Molecules. 2021 Mar 5;26(5):1403. doi: 10.3390/molecules26051403.
Tart cherries ( L.) are a rich source of anthocyanins. They are phytochemical flavonoids found in red and blue fruits, and vegetables that can reduce hyperlipidemia. Visceral Adipose Tissue (VAT) has emerged as a major player in driving obesity-related inflammatory response.
This study has investigated the potential positive effects of tart cherries on rats with Diet-Induced Obesity (DIO). In particular, the inflammatory status in retroperitoneal (RPW) and perigonadal (PGW) adipose tissue were studied. Rats were fed for 17 weeks with a hypercaloric diet with the supplementation of tart cherries seeds powder (DS) and seeds powder plus tart cherries juice containing 1mg of anthocyanins (DJS). In RPW and PGW, expression of CRP, IL-1 β, TNF-α, CCL2 and CD36, were measured by qRT-PCR, Western blot and immunohistochemistry techniques.
No differences in the weight of RPW and PGW animals were found between DS and DJS groups compared to DIO rats. However, an increase of inflammatory markers was observed in DIO group in comparison with control lean rats. A modulation of these markers was evident upon tart cherry supplementation.
Study results suggest that tart cherry enriched-diet did not modify the accumulation of visceral fat, but it decreased inflammatory markers in both tissues. Therefore, this supplementation could be useful, in combination with healthy lifestyles, to modify adipose tissue cell metabolism limiting-obesity related organ damage.
酸樱桃（L.）是花青素的丰富来源。它们是存在于红色和蓝色水果和蔬菜中的植物化学类黄酮，可以减少高血脂。内脏脂肪组织（VAT）已成为驱动肥胖相关炎症反应的主要因素。
本研究调查了酸樱桃对饮食诱导肥胖（DIO）大鼠的潜在积极影响。特别研究了腹膜后（RPW）和性腺旁（PGW）脂肪组织的炎症状态。大鼠用高卡路里饮食喂养 17 周，并补充酸樱桃种子粉（DS）和含有 1mg 花青素的酸樱桃种子粉加酸樱桃汁（DJS）。通过 qRT-PCR、Western blot 和免疫组织化学技术测量 RPW 和 PGW 中 CRP、IL-1β、TNF-α、CCL2 和 CD36 的表达。
与 DIO 大鼠相比，DS 和 DJS 组的 RPW 和 PGW 动物体重无差异。然而，与对照瘦大鼠相比，DIO 组的炎症标志物增加。在酸樱桃补充后，这些标志物的调节明显。
研究结果表明，富含酸樱桃的饮食并没有改变内脏脂肪的积累，但它降低了两种组织中的炎症标志物。因此，这种补充剂与健康的生活方式相结合，可能有助于改变脂肪组织细胞代谢，限制肥胖相关的器官损伤。
