Mohamed Ali, Menon Harry, Chulkina Marina, Yee Nelson S, Pinchuk Irina V
Division of Hematology-Oncology, Department of Medicine, Penn State Health Milton S. Hershey Medical Center, Penn State Cancer Institute, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Mechanisms of Carcinogenesis Program, Division of Gastroenterology, Department of Medicine, Penn State Health Milton S. Hershey Medical Center, Penn State Cancer Institute, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Biomedicines. 2021 Mar 5;9(3):259. doi: 10.3390/biomedicines9030259.
Colon adenocarcinoma is one of the most common malignancies, and it is highly lethal. Chemotherapy plays an important role in the treatment of colon cancer at various stages of the disease. The gut microbiome has emerged as a key player in colon cancer development and progression, and it can also alter the therapeutic agent's efficacy and toxicities. Antibiotics can directly and/or indirectly affect the balance of the gut microbiome and, therefore, the clinical outcomes. In this article, we provided an overview of the composition of the gut microbiome under homeostasis and the mechanistic links between gut microbiota and colon cancer. The relationship between the use of oral antibiotics and colon cancer, as well as the impact of the gut microbiome on the efficacy and toxicities of chemotherapy in colon cancer, are discussed. Potential interventions to modulate microbiota and improve chemotherapy outcomes are discussed. Further studies are indicated to address these key gaps in the field and provide a scientific basis for the design of novel microbiota-based approaches for prevention/use as adjuvant therapeutics for patients with colon cancer.
结肠癌是最常见的恶性肿瘤之一，且具有很高的致死性。化疗在结肠癌疾病各个阶段的治疗中发挥着重要作用。肠道微生物群已成为结肠癌发生和发展的关键因素，它还会改变治疗药物的疗效和毒性。抗生素可直接和/或间接影响肠道微生物群的平衡，进而影响临床结局。在本文中，我们概述了稳态下肠道微生物群的组成以及肠道微生物群与结肠癌之间的机制联系。讨论了口服抗生素的使用与结肠癌之间的关系，以及肠道微生物群对结肠癌化疗疗效和毒性的影响。还讨论了调节微生物群并改善化疗结果的潜在干预措施。需要进一步开展研究以填补该领域的这些关键空白，并为设计基于微生物群的新型预防方法/用作结肠癌患者的辅助治疗提供科学依据。
