Kamiya Koji, Komine Mayumi, Ohtsuki Mamitaro
Department of Dermatology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan.
J Clin Med. 2021 Mar 30;10(7):1390. doi: 10.3390/jcm10071390.
Psoriasis is a chronic, immune-mediated inflammatory disease that predominantly affects the skin and joints. The recent therapeutic development for psoriasis has been remarkable and biologics have dramatically changed the treatment of psoriasis. In moderate-to-severe cases, systemic therapies are required to control their symptoms and biologics can provide greater efficacy when compared with other types of therapies. The coronavirus disease (COVID-19) pandemic has had a great impact on the lives of many people and has worsened substantially worldwide. During the ongoing COVID-19 pandemic, it still remains unclear whether biologics suppress the immune system and increase the risk of COVID-19. In this review, we have summarized the experience with biologics used for treating psoriasis during the COVID-19 pandemic. Biologics seem to be beneficial to COVID-19 infection. Shared decision-making that is based on updated information is highlighted in the time of COVID-19.
银屑病是一种慢性、免疫介导的炎症性疾病,主要影响皮肤和关节。银屑病的近期治疗进展显著,生物制剂极大地改变了银屑病的治疗方式。在中重度病例中,需要采用全身治疗来控制症状,与其他类型的治疗相比,生物制剂能提供更高的疗效。冠状病毒病(COVID-19)大流行对许多人的生活产生了巨大影响,且在全球范围内大幅恶化。在持续的COVID-19大流行期间,生物制剂是否会抑制免疫系统并增加感染COVID-19的风险仍不明确。在本综述中,我们总结了COVID-19大流行期间使用生物制剂治疗银屑病的经验。生物制剂似乎对COVID-19感染有益。在COVID-19时期,基于最新信息的共同决策受到了重视。