Nutrigenomics Research Group, Department of Biochemistry and Biotechnology, Universitat Rovira i Virgili, 43007 Tarragona, Spain.
Nutrients. 2021 Mar 30;13(4):1142. doi: 10.3390/nu13041142.
The antihypertensive effect of wine lees (WL) has been previously evidenced. In this study, the antihypertensive properties of different doses of WL were evaluated in spontaneously hypertensive rats (SHR). In addition, the blood pressure (BP)-lowering effect of dried (dealcoholized) WL powder (WLPW) and the mechanisms involved in its functionality were investigated. Furthermore, a possible hypotensive effect of WLPW was discarded in Wistar-Kyoto (WKY) rats. The administration of WL at different doses caused a dose-dependent decrease in BP of SHR up to 5.0 mL/kg bw, exhibiting the maximum decrease at 6 h post-administration. WLPW caused a greater drop in BP than WL, showing an antihypertensive effect higher and more prolonged than the drug Captopril. Moreover, the BP-lowering effect of WLPW was specific to the hypertensive state since an undesirable hypotensive effect in normotensive WKY rats was ruled out. Finally, WLPW improved oxidative stress and increased the activity of the antioxidant endogen system of SHR. These results suggest that WLPW could be used as functional ingredient for foods or nutraceuticals to ameliorate hypertension. Nevertheless, further clinical studies are needed to evaluate its long-term antihypertensive efficiency.
酒渣（WL）具有降压作用已得到证实。本研究评估了不同剂量 WL 对自发性高血压大鼠（SHR）的降压特性。此外，还研究了干燥（脱醇）WL 粉（WLPW）的降压作用及其作用机制，并排除了 WLPW 在 Wistar-Kyoto（WKY）大鼠中的降压作用。WL 的不同剂量给药可使 SHR 的血压呈剂量依赖性下降，最大下降幅度出现在给药后 6 小时。与 WL 相比，WLPW 引起的血压下降更大，其降压作用高于且持续时间长于药物卡托普利。此外，WLPW 的降压作用是针对高血压状态的，因为排除了在正常血压的 WKY 大鼠中出现的不良降压作用。最后，WLPW 改善了氧化应激并增加了 SHR 抗氧化内源系统的活性。这些结果表明，WLPW 可用作功能性食品或营养保健品的成分，以改善高血压。然而，仍需要进一步的临床研究来评估其长期的降压效果。
