儿童新型冠状病毒肺炎与先天免疫的关系：综述
The Relationship between COVID-19 and Innate Immunity in Children: A Review.
作者信息
Valentini Piero, Sodero Giorgio, Buonsenso Danilo
机构信息
Istituto di Pediatria, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.
出版信息
Children (Basel). 2021 Mar 30;8(4):266. doi: 10.3390/children8040266.
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus responsible for the pandemic viral pneumonia that was first identified in Wuhan, China, in December 2019, and has since rapidly spread around the world. The number of COVID-19 cases recorded in pediatric age is around 1% of the total. The immunological mechanisms that lead to a lower susceptibility or severity of pediatric patients are not entirely clear. At the same time, the immune dysregulation found in those children who developed the multisystem inflammatory syndrome (MIC-S) is not yet fully understood. The aim of this review is to analyze the possible influence of children's innate immune systems, considering the risk of contracting the virus, spreading it, and developing symptomatic disease or complications related to infection.
摘要
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）是导致大流行性病毒性肺炎的病毒，该肺炎于2019年12月在中国武汉首次发现，此后迅速在全球传播。记录在案的儿童COVID-19病例数约占总数的1%。导致儿科患者易感性或严重程度较低的免疫机制尚不完全清楚。与此同时，在那些发展为多系统炎症综合征（MIC-S）的儿童中发现的免疫失调尚未完全了解。本综述的目的是分析儿童先天免疫系统的可能影响，同时考虑感染病毒的风险、传播病毒的风险以及出现与感染相关的症状性疾病或并发症的风险。
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3
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4
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