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一种源自水牛奶酪的新型血管活性肽“PG1”可预防血管紧张素引发的高血压。

A Novel Vasoactive Peptide "PG1" from Buffalo Ice-Cream Protects from Angiotensin-Evoked High Blood Pressure.

作者信息

Carrizzo Albino, Basilicata Manuela Giovanna, Pepe Giacomo, Sørensen Kasper K, Ciccarelli Michele, Sarno Veronica Di, Damato Antonio, Venturini Eleonora, Borrelli Anna, Musella Simona, Abate Mario, Pietro Paola Di, Ostacolo Carmine, Campiglia Pietro, Vecchione Carmine

机构信息

Department of Medicine and Surgery, University of Salerno, 84081 Baronissi, SA, Italy.

IRCCS Neuromed, Vascular Pathophysiology Unit, 86077 Pozzilli, IS, Italy.

出版信息

Antioxidants (Basel). 2021 Mar 12;10(3):441. doi: 10.3390/antiox10030441.

DOI:10.3390/antiox10030441
PMID:33809389
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8002072/
Abstract

BACKGROUND

Arterial hypertension is the most important risk factor for cardiovascular diseases, myocardial infarction, heart failure, renal failure and peripheral vascular disease. In the last decade, milk-derived bioactive peptides have attracted attention for their beneficial cardiovascular properties.

METHODS

Here, we combined in vitro chemical assay such as LC-MS/MS analysis of buffalo ice cream, ex vivo vascular studies evaluating endothelial and smooth muscle responses using pressure myograph, and translational assay testing in vivo the vascular actions of PG1 administration in murine models.

RESULTS

We demonstrate that a novel buffalo ice-cream-derived pentapeptide "QKEPM", namely PG1, is a stable peptide that can be obtained at higher concentration after gastro-intestinal digestions (GID) of buffalo ice-cream (BIC). It owns potent vascular effect in counteract the effects of angiotensin II-evoked vasoconstriction and high blood pressure levels. Its effects are mediated by the inhibitory effect on AT1 receptor leading to a downregulation of p-ERK½/Rac1-GTP and consequent reduction of oxidative stress.

CONCLUSIONS

These results strongly candidate PG1, as a novel bioactive peptide for the prevention and management of hypertension, thus expanding the armamentarium of preventive strategies aimed at reducing the incidence and progression of hypertension and its related cardiovascular complications.

摘要

背景

动脉高血压是心血管疾病、心肌梗死、心力衰竭、肾衰竭和外周血管疾病最重要的危险因素。在过去十年中，源自牛奶的生物活性肽因其有益的心血管特性而受到关注。

方法

在此，我们结合了体外化学分析，如对水牛奶冰淇淋进行液相色谱 - 串联质谱（LC-MS/MS）分析；离体血管研究，使用压力肌动描记器评估内皮和平滑肌反应；以及在小鼠模型中对PG1给药的血管作用进行体内测试的转化分析。

结果

我们证明，一种源自水牛奶冰淇淋的新型五肽“QKEPM”，即PG1，是一种稳定的肽，在水牛奶冰淇淋（BIC）经胃肠道消化（GID）后可以更高浓度获得。它在抵消血管紧张素II引起的血管收缩和高血压水平方面具有强大的血管效应。其作用是通过对AT1受体的抑制作用介导的，导致p-ERK½/Rac1-GTP下调，从而减少氧化应激。

结论

这些结果有力地表明PG1是一种用于预防和管理高血压的新型生物活性肽，从而扩大了旨在降低高血压及其相关心血管并发症的发病率和进展的预防策略的范围。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9883/8002072/8bb95767b32a/antioxidants-10-00441-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9883/8002072/47fb78e59f40/antioxidants-10-00441-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9883/8002072/bf4ef46d0ac7/antioxidants-10-00441-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9883/8002072/b3d36ed084e7/antioxidants-10-00441-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9883/8002072/472e11b9aa35/antioxidants-10-00441-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9883/8002072/8bb95767b32a/antioxidants-10-00441-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9883/8002072/47fb78e59f40/antioxidants-10-00441-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9883/8002072/bf4ef46d0ac7/antioxidants-10-00441-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9883/8002072/b3d36ed084e7/antioxidants-10-00441-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9883/8002072/472e11b9aa35/antioxidants-10-00441-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9883/8002072/8bb95767b32a/antioxidants-10-00441-g005.jpg

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