Sleep and Health Research Program, Department of Psychiatry, University of Arizona College of Medicine-Tucson, Tucson, AZ 85724, USA.
Department of Psychology, Northumbria University, Newcastle-upon-Tyne NE1 8ST, UK.
Int J Environ Res Public Health. 2021 Mar 16;18(6):3044. doi: 10.3390/ijerph18063044.
Despite the high prevalence of subclinical sleep disturbances, existing treatments are either potent prescription medications or over-the-counter supplements with minimal scientific support and numerous side effects. However, preliminary evidence shows that polyphenols such as rosmarinic acid and epigallocatechin gallate can support healthy sleep without significant side effects. Therefore, the present study examined whether a polyphenol botanical blend (PBB) could improve sleep and/or daytime functioning in individuals with subclinical sleep disturbances. A total of 89 individuals completed a double-blind, randomized trial of daily treatment with PBB ( = 43) or placebo ( = 46) 30 min before bed for 30 days. Participants were monitored for changes in sleep (by sleep diary and an activity tracker), mood, and neurocognitive functioning. After 30 days, PBB improved diary sleep quality ( = 0.008) and reduced insomnia severity ( = 0.044) when compared to placebo. No other changes in sleep outcomes were observed. Additionally, PBB did not impair neurocognitive functioning, and some improvement was noted in vigilant attention, working memory, and risk assessment. Among individuals with subclinical sleep disturbances, PBB improved sleep quality, insomnia severity, and neurocognitive functioning over placebo. These findings indicate that polyphenol compounds may be useful for improving certain aspects of sleep without compromising neurocognitive functioning.
尽管亚临床睡眠障碍的患病率很高，但现有的治疗方法要么是强效的处方药物，要么是未经充分科学验证且副作用众多的非处方补充剂。然而，初步证据表明，迷迭香酸和表没食子儿茶素没食子酸酯等多酚类化合物可以在没有明显副作用的情况下支持健康睡眠。因此，本研究旨在探讨多酚植物混合物（PBB）是否可以改善亚临床睡眠障碍个体的睡眠和/或日间功能。共有 89 名个体完成了一项为期 30 天的双盲、随机试验，每天睡前 30 分钟接受 PBB（=43 人）或安慰剂（=46 人）治疗。通过睡眠日记和活动追踪器监测参与者的睡眠（睡眠质量和日间功能）、情绪和神经认知功能的变化。30 天后，与安慰剂相比，PBB 改善了日记睡眠质量（=0.008）和失眠严重程度（=0.044）。未观察到睡眠结果的其他变化。此外，PBB 并未损害神经认知功能，警觉注意力、工作记忆和风险评估方面有一些改善。在亚临床睡眠障碍个体中，PBB 改善了睡眠质量、失眠严重程度和神经认知功能，优于安慰剂。这些发现表明，多酚化合物可能有助于改善睡眠质量，而不会影响神经认知功能。
