Dept. Metabolism and Nutrition, Institute of Food Science, Technology and Nutrition (ICTAN-CSIC), Madrid, Spain; CIBER of Diabetes and Associated Metabolic Disease (CIBERDEM), ISCIII, Madrid, Spain; Division of General Medicine and Center of Excellence for Sleep & Circadian Research, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA.
Division of General Medicine and Center of Excellence for Sleep & Circadian Research, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA.
Sleep Med Rev. 2023 Dec;72:101844. doi: 10.1016/j.smrv.2023.101844. Epub 2023 Aug 28.
Polyphenols are plant compounds with several biological activities. This review aims to summarize current knowledge on the potential role of polyphenols in modulating sleep. A total of 28 preclinical studies, 12 intervention studies and four observational studies exploring the role of polyphenol intake on sleep were identified. From animal studies, 26 out of the 28 studies found beneficial effects of polyphenols on sleep architecture. Three out of four human observational studies found a beneficial association between polyphenol intake and sleep parameters. And, among clinical intervention studies, eight from a total of 12 studies found some beneficial effect of polyphenol intake on various sleep parameters, although some discrepancies between studies were found. Overall, emerging evidence suggests a benefit of polyphenol intake on sleep. Several mechanisms of action have been suggested, ranging from effects on neurotransmitters to an action through the gut-brain axis. However, more research in this field is needed, emphasizing the use of nutritional doses in mechanistic studies and interventions targeting participants with sleep problems. This would allow to elucidate whether an additional biological effect of polyphenols is modulation of sleep, a behavior associated with adverse health outcomes.
多酚是具有多种生物活性的植物化合物。本综述旨在总结多酚在调节睡眠方面的潜在作用的现有知识。共确定了 28 项临床前研究、12 项干预研究和 4 项观察性研究，探讨了多酚摄入对睡眠的作用。在动物研究中，28 项研究中有 26 项发现多酚对睡眠结构有有益影响。四项人类观察性研究中有三项发现多酚摄入与睡眠参数之间存在有益关联。在临床干预研究中，总共 12 项研究中有 8 项发现多酚摄入对各种睡眠参数有一些有益影响，但研究之间存在一些差异。总体而言，新出现的证据表明多酚摄入对睡眠有益。已经提出了几种作用机制，从对神经递质的影响到通过肠道-大脑轴的作用。然而，该领域需要更多的研究，强调在机制研究和针对有睡眠问题的参与者的干预措施中使用营养剂量。这将有助于阐明多酚的另一个生物学效应是否是调节睡眠，这种行为与不良健康结果有关。
