Opławski Marcin, Smoczyńska Magdalena, Grabarek Beniamin Oskar, Boroń Dariusz
Department of Gynecology and Obstetrics with Gynecologic Oncology, Ludwik Rydygier Memorial Specialized Hospital, 31-826 Kraków, Poland.
Department of Rehabilitation Psychology, Ludwik Rydygier Collegium Medium, Mikołaj Kopernik's University CM UMK, 30-835 Bydgoszcz, Poland.
J Clin Med. 2021 Mar 16;10(6):1228. doi: 10.3390/jcm10061228.
This work aimed to assess the influence of oncological combination therapy that was done on endometrial or ovarian cancer and how the urinary system is influenced as well as the quality of life in comparison to a group of female patients after the removal of the uterus with appendages due to endometrial cancer, which did not require the supplementation of therapy after operative treatment. The study included 87 patients with endometrial cancer, where, after the removal of the uterus, there was no need for conducting adjuvant therapy (C), as well as 92 female patients with endometrial cancer or 38 patients with ovarian cancer in whom combination therapy was conducted (group A, B). The assessment of the quality of life was conducted using the questionnaires: Satisfaction Life Scale (SWLS), Incontinence Impact Questionnaire, Short Form (IIQ-7), and Urogenital Distress Inventory (UDI-6) for three, six, nine, and 12 months after the conclusion of oncological treatment. It was observed that there was a statistically significant decrease in the quality of life in female patients who underwent combination therapy in comparison to a group in whose treatment only included surgery ( < 0.05). The risk of developing urinary incontinence increases alongside an increase in the scope of the operation and in the case of supplementing treatment with brachytherapy in comparison to chemotherapy.
这项研究旨在评估针对子宫内膜癌或卵巢癌进行的肿瘤联合治疗的影响,以及与一组因子宫内膜癌切除子宫及附件后无需术后补充治疗的女性患者相比,泌尿系统受到的影响以及生活质量。该研究纳入了87例子宫内膜癌患者,这些患者在切除子宫后无需进行辅助治疗(C组),以及92例接受联合治疗的子宫内膜癌女性患者或38例接受联合治疗的卵巢癌患者(A组、B组)。在肿瘤治疗结束后的三个月、六个月、九个月和十二个月,使用以下问卷对生活质量进行评估:生活满意度量表(SWLS)、尿失禁影响问卷简表(IIQ - 7)和泌尿生殖系统困扰量表(UDI - 6)。研究发现,与仅接受手术治疗的组相比,接受联合治疗的女性患者的生活质量在统计学上有显著下降(<0.05)。与化疗相比,随着手术范围的扩大以及在补充近距离放射治疗的情况下,发生尿失禁的风险会增加。