Carotenuto Antonio, Scandurra Cristiano, Costabile Teresa, Lavorgna Luigi, Borriello Giovanna, Moiola Lucia, Inglese Matilde, Trojsi Francesca, Petruzzo Martina, Ianniello Antonio, Nozzolillo Agostino, Cellerino Maria, Boffa Giacomo, Rosa Laura, Chiodi Alessandro, Servillo Giuseppe, Moccia Marcello, Bonavita Simona, Filippi Massimo, Petracca Maria, Brescia Morra Vincenzo, Lanzillo Roberta
Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, 80131 Naples, Italy.
Multiple Sclerosis Centre, II Division of Neurology, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
J Clin Med. 2021 Mar 16;10(6):1234. doi: 10.3390/jcm10061234.
Physical disability impacts psychosocial wellbeing in people with multiple sclerosis. However, the role of physical activity in this context is still debated. By taking advantage of a previous survey, conducted online from 22 April to 7 May 2020, we performed a post-hoc analysis with the aim to assess the associations between disability, physical exercise, and mental health in multiple sclerosis. We retrieved the following data: (i) sociodemographic information, (ii) changes in lifestyle (including exercise), (iii) physical disability, as measured with the Patient-Determined Disease Steps scale, and (iv) anxiety feelings and depressive symptoms assessed via the items included in the Quality of Life in Neurological Disorders measurement system. Examination of the interaction plot showed that the effect of disability on depression, but not on anxious symptoms, was significant for all levels of physical exercise (low: b = 1.22, 95% C.I. 0.85, 1.58, < 0.001; moderate: b = 0.95, 95% C.I. 0.66, 1.24, < 0.001; and high: b = 0.68, 95% C.I. 0.24, 1.13, = 0.003). Based on these data, we can conclude that disability significantly impacted depression during the COVID-19 pandemic, with physical activity playing a moderating role. Our results suggest that favoring exercise in multiple sclerosis (MS) would ameliorate psychological wellbeing regardless of the level of physical disability.
身体残疾会影响多发性硬化症患者的心理社会幸福感。然而，在这种情况下体育活动的作用仍存在争议。利用2020年4月22日至5月7日在线进行的一项先前调查，我们进行了一项事后分析，旨在评估多发性硬化症患者的残疾、体育锻炼与心理健康之间的关联。我们获取了以下数据：（i）社会人口统计学信息，（ii）生活方式的变化（包括锻炼），（iii）用患者确定的疾病阶段量表测量的身体残疾，以及（iv）通过神经疾病生活质量测量系统中的项目评估的焦虑情绪和抑郁症状。对交互图的检查表明，在所有体育锻炼水平下，残疾对抑郁的影响显著，但对焦虑症状的影响不显著（低水平：b = 1.22，95%置信区间0.85，1.58，< 0.001；中等水平：b = 0.95，95%置信区间0.66，1.24，< 0.001；高水平：b = 0.68，95%置信区间0.24，1.13，= 0.003）。基于这些数据，我们可以得出结论，在新冠疫情期间，残疾对抑郁有显著影响，体育活动起到了调节作用。我们的结果表明，无论身体残疾程度如何，鼓励多发性硬化症（MS）患者进行锻炼都将改善其心理健康。
