Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore.
Cells. 2021 Mar 16;10(3):658. doi: 10.3390/cells10030658.
In presynaptic terminals, synaptic vesicles (SVs) are found in a discrete cluster that includes a reserve pool that is mobilized during synaptic activity. Synapsins serve as a key protein for maintaining SVs within this reserve pool, but the mechanism that allows synapsins to do this is unclear. This mechanism is likely to involve synapsins either cross-linking SVs, thereby anchoring SVs to each other, or creating a liquid phase that allows SVs to float within a synapsin droplet. Here, we summarize what is known about the role of synapsins in clustering of SVs and evaluate experimental evidence supporting these two models.
在突触前末端，突触小泡 (SVs) 存在于一个离散的簇中，其中包括一个储备池，该储备池在突触活动期间被动员。突触结合蛋白作为将 SVs 维持在该储备池中的关键蛋白，但允许突触结合蛋白这样做的机制尚不清楚。该机制可能涉及突触结合蛋白交联 SVs，从而将 SVs 彼此锚定，或者创建一个液相，使 SVs 能够在突触结合蛋白滴内漂浮。在这里，我们总结了突触结合蛋白在 SV 聚类中的作用，并评估了支持这两种模型的实验证据。
